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How to get fromSanibel Island to South Carolinaby plane, bus, train, taxi, or car

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There are 7 ways to get from Sanibel Island to South Carolina by plane, bus, train, taxi, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Greenville–Spartanburg International Airport

    best
    1. Fly from Ft. Myers (RSW) to Greenville–Spartanburg International Airport (GSP)plane plane RSW - GSP
    2h 39m
    $224–827

  2. Drive 547.1 mi

    cheapest
    1. Drive from Sanibel Island to Charlestoncar car 547.1 mi
    10h 4m
    $100–145

  3. Bus, train via Orlando (Amtrak)

    1. Take the bus from Fort Myers Amtrak Bus Stop to Orlandobus bus Amtrak Thruway Connecting Service
    2. Take the train from Orlando to Charleston Amtrak Stationtrain train Silver Meteor
    17h 3m
    $263–456

  4. Bus, train, taxi

    1. Take the bus from Fort Myers Amtrak Bus Stop to Orlandobus bus
    2. Take the train from Orlando to Savannah Stationtrain train
    3. Take the taxi from Savannah Station to Bluffton Transfer Centertaxi taxi
    4. Take the bus from Bluffton Transfer Center to Walmartbus bus 320
    5. Take the taxi from Walmart to Dorchester Village Shopping Center Park & Ridetaxi taxi
    19h 54m

  5. Fly to Charlotte Douglas International Airport, taxi

    1. Fly from Ft. Myers (RSW) to Charlotte Douglas International Airport (CLT)plane plane RSW - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    3h 12m
    $259–832

  6. Fly to Charleston International Airport

    1. Fly from Ft. Myers (RSW) to Charleston International Airport (CHS)plane plane RSW - CHS
    3h 13m
    $171–634

  7. Bus, train

    1. Take the bus from Fort Myers Bus Stop to Hollywood Sheridan Trirail Stationbus bus FlixBus 2421
    2. Take the train from Fort Lauderdale Amtrak Station to Charleston Amtrak Stationtrain train Silver Meteor
    17h 58m
    $298–565

Ft. Myers (RSW) to Greenville–Spartanburg International Airport (GSP) flights

Calendar29Weekly Planes
Duration3h 39mAverage Duration
Ticket$124Cheapest Price
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Questions & Answers

Map of how to get from Sanibel Island to South Carolina.ExpandLaunch map view
  • Distance: 614.6 mi
  • Duration: 2h 39m

What companies run services between Sanibel Island, FL, USA and South Carolina, USA?

Breeze Airways, Delta, and two other airlines fly from Ft. Myers (RSW) to Greenville–Spartanburg International Airport (GSP) 4 times a day.

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