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How to get fromSanibel Island to Tupeloby plane, car, bus (Flixbus, Greyhound), or bus (Greyhound)

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There are 5 ways to get from Sanibel Island to Tupelo by plane, car, bus (Flixbus, Greyhound), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Golden Triangle Regional Airport, drive

    best
    1. Fly from Ft. Myers (RSW) to Golden Triangle Regional Airport (GTR)plane plane RSW - GTR
    2. Drive from Golden Triangle Regional Airport (GTR) to Tupelocar car
    7h 23m
    $182–577

  2. Drive 781 mi

    cheapest
    1. Drive from Sanibel Island to Tupelocar car 781 mi
    14h 41m
    $143–206

  3. Bus

    1. Take the bus from Fort Myers to Tampa USFbus bus
    2. Take the bus from University of South Florida to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Tupelobus bus
    18h 41m
    $224–380

  4. Fly to Tupelo Regional Airport

    1. Fly from Ft. Myers (RSW) to Tupelo Regional Airport (TUP)plane plane RSW - TUP
    5h 9m
    $200–658

  5. Bus via Gainesville

    1. Take the bus from Fort Myers to Gainesville - UFbus bus
    2. Take the bus from Gainesville - UF to Atlanta - Civic Center MARTA Stationbus bus
    3. Take the bus from Atlanta Bus Station to Tupelobus bus
    19h 5m
    $267–468

Ft. Myers (RSW) to Golden Triangle Regional Airport (GTR) flights

Calendar22Weekly Planes
Duration6h 55mAverage Duration
Ticket$95Cheapest Price
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Questions & Answers

Map of how to get from Sanibel Island to Tupelo.ExpandLaunch map view
  • Distance: 714.8 mi
  • Duration: 7h 23m

What companies run services between Sanibel Island, FL, USA and Tupelo, MS, USA?

You can take a vehicle from Sanibel Island to Tupelo via Fort Myers, University of South Florida, Atlanta Bus Station, and Tupelo in around 18h 41m. Alternatively, Southwest Airlines, Corporate Flight Management Inc, and two other airlines fly from Ft. Myers (RSW) to Tupelo Regional Airport (TUP) 3 times a day.

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