Rome2Rio

How to get fromSanibel to Key Largoby taxi, bus, car, bus (Flixbus, Greyhound), or train

Find Transport to Key Largo

See all options

There are 4 ways to get from Sanibel to Key Largo by taxi, bus, car, bus (Flixbus, Greyhound), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi, bus

    best
    1. Take the taxi from Sanibel to Naples, FLtaxi taxi
    2. Take the bus from Naples, FL to Miami Airportbus bus
    3. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    5h 28m
    $173–230

  2. Drive 184.7 mi

    cheapest
    1. Drive from Sanibel to Key Largocar car 184.7 mi
    3h 51m
    $34–49

  3. Bus

    1. Take the bus from Fort Myers Bus Stop to Miami Airport Stationbus bus FlixBus 2421
    2. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus Greyhound US0720s
    5h 58m
    $94–129

  4. Line 50 bus, line 140 bus, bus, line 2600 train, line 602 bus

    1. Take the bus from Mcgregor Blvd @ Davis Rd to South Fort Myers Transfer/P&Rbus bus 50
    2. Take the bus from South Fort Myers Transfer/P&R to Rosa Parks Transportation Ctrbus bus 140
    3. Take the bus from Fort Myers Bus Stop to Miami Airport Stationbus bus
    4. Take the train from Miami Airport Station to Dadeland South Stat.Rail Southboundtrain train
    5. Take the bus from Dadeland South Metrorail Station to Sw 344 St Park-And-Ridebus bus 602 / ...
    6. Take the bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largobus bus 301
    9h 21m
    $58–82

Questions & Answers

Map of how to get from Sanibel to Key Largo.ExpandLaunch map view
  • Distance: 213.3 mi
  • Duration: 5h 28m

What companies run services between Sanibel, FL, USA and Key Largo, FL, USA?

You can take a vehicle from Sanibel to Key Largo Bus Stop via Fort Myers Bus Stop and Miami Airport Station in around 5h 58m.

Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound