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How to get fromSanibel to Key West (Island)by ferry, bus (Flixbus, Greyhound), car, taxi, plane, or bus

Find Transport to Key West (Island)

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There are 5 ways to get from Sanibel to Key West (Island) by ferry, bus (Flixbus, Greyhound), car, taxi, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Ferry

    best
    1. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry Fort Myers Beach
    4h 19m
    $166–172

  2. Drive  281.8 mi

    cheapest
    1. Drive from Sanibel to Key Westcar car 281.8 mi
    6h 7m
    $52–75

  3. Bus

    1. Take the bus from Fort Myers Bus Stop to Miami Airport Stationbus bus FlixBus 2421
    2. Take the bus from Miami Airport Station to Key West Airportbus bus Greyhound US0720s
    11h 13m
    $76–117

  4. Taxi to Ft. Myers, fly

    1. Take the taxi from Sanibel to Ft-Myers-Airport-RSWtaxi taxi
    2. Fly from Ft. Myers (RSW) to Key West International Airport (EYW)plane plane RSW - EYW
    5h 22m
    $157–505

  5. Bus to Miami International Airport, fly

    1. Take the bus from Fort Myers 7-11 to Miami Airportbus bus
    2. Fly from Miami International Airport (MIA) to Key West International Airport (EYW)plane plane MIA - EYW
    5h 25m
    $133–335

Ft. Myers (RSW) to Key West International Airport (EYW) flights

Calendar36Weekly Planes
Duration5h 53mAverage Duration
Ticket$88Cheapest Price
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Comparing Your Travel Options

Map of how to get from Sanibel to Key West (Island).ExpandLaunch map view
  • Distance: 148.4 mi
  • Duration: 4h 19m

What companies run services between Sanibel, FL, USA and Key West (Island), FL, USA?

Key West Express operates a ferry from Fort Myers Beach, FL to Key West, FL once daily. Tickets cost $130 and the journey takes 4h. Alternatively, you can take a vehicle from Sanibel to Key West Airport via Mcgregor Blvd @ Davis Rd, South Fort Myers Transfer/P&R, Fort Myers Bus Stop, and Miami Airport Station in around 11h 13m.

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