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How to get fromSanta Ana to Guayaquilby taxi, bus, or car

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There are 4 ways to get from Santa Ana to Guayaquil by taxi, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi, bus

    best
    1. Take the taxi from Santa Ana to Jipijapataxi taxi
    2. Take the bus from Jipijapa to Terminal Terrestre de Guayaquilbus bus Manta
    2h 18m
    $5–14

  2. Drive 160.3 km

    1. Drive from Santa Ana to Guayaquilcar car 160.3 km
    2h 36m
    $10–14

  3. Taxi

    1. Take the taxi from Santa Ana to Guayaquiltaxi taxi 160.3 km
    2h 36m
    $90–110

  4. Bus

    1. Take the bus from Portoviejo to Guayaquilbus bus Portoviejo
    3h 30m
    $7–15

Questions & Answers

Map of how to get from Santa Ana to Guayaquil.ExpandLaunch map view
  • Distance: 173.4 km
  • Duration: 2h 18m

What companies run services between Santa Ana, Manabí, Ecuador and Guayaquil, Ecuador?

Reina del Camino operates a bus from Portoviejo to Guayaquil every 30 minutes. Tickets cost $7–15 and the journey takes 3h 10m.

Bus operators
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Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including Need to know: Jadrolinija, 5 incredible day trips from Florence by train, and What are the different types of Renfe trains in Spain? - to help you get the most out of your next trip.