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How to get fromSanta Ana to Buffaloby plane, train (Amtrak), bus (Greyhound), car, train, or bus

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There are 6 ways to get from Santa Ana to Buffalo by plane, train (Amtrak), bus (Greyhound), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Wayne Airport Orange County

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Buffalo Niagara International Airport (BUF)plane plane SNA - BUF
    7h 31m
    $330–1,262

  2. Train to Los Angeles International Airport, fly

    cheapest
    1. Take the train from Santa Ana to Los Angelestrain train
    2. Fly from Los Angeles International Airport (LAX) to Buffalo Niagara International Airport (BUF)plane plane LAX - BUF
    8h 40m
    $290–1,165

  3. Train (Amtrak)

    1. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train Southwest Chief
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    2d 8h
    $879–1,999

  4. Bus

    1. Take the bus from Santa Ana to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Columbusbus bus
    4. Take the bus from Columbus - Mound St to Buffalo, NYbus bus
    2d 13h
    $400–773

  5. Drive 2,526.7 mi

    1. Drive from Santa Ana to Buffalocar car 2,526.7 mi
    40h 18m
    $462–667

  6. Train, bus

    1. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    2. Take the bus from Chicago to Clevelandbus bus
    3. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    2d 8h
    $752–1,644

Santa Ana to Buffalo by train (Amtrak)

Calendar7Weekly Trains
Duration2d 8hAverage Duration
Ticket$879Cheapest Price
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Questions & Answers

Map of how to get from Santa Ana to Buffalo.ExpandLaunch map view
  • Distance: 2,213.2 mi
  • Duration: 7h 31m

What companies run services between Santa Ana, CA, USA and Buffalo, NY, USA?

United Airlines, Southwest Airlines, and two other airlines fly from John Wayne Airport Orange County (SNA) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, you can take a train from Santa Ana to Buffalo via Fullerton Amtrak Station, Chicago Union Station, and Buffalo Depew Station in around 2d 8h.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

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