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How to get fromSanta Ana to Columbiaby plane, train, bus, bus (Greyhound), or car

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There are 5 ways to get from Santa Ana to Columbia by plane, train, bus, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Wayne Airport Orange County

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Columbia Regional Airport (COU)plane plane SNA - COU
    6h 15m
    $208–698

  2. Train to Los Angeles International Airport, fly

    cheapest
    1. Take the train from Santa Ana to Los Angelestrain train
    2. Fly from Los Angeles International Airport (LAX) to Columbia Regional Airport (COU)plane plane LAX - COU
    9h 17m
    $188–651

  3. Train, bus

    1. Take the train from Fullerton Amtrak Station to Kansas Citytrain train Southwest Chief
    2. Take the bus from Kansas City Bus Station to Columbiabus bus Greyhound US0175s
    39h 54m
    $576–1,249

  4. Bus (Greyhound)

    1. Take the bus from Santa Ana Bus Stop to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Columbiabus bus
    47h
    $308–609

  5. Drive 1,672.8 mi

    1. Drive from Santa Ana to Columbiacar car 1,672.8 mi
    28h 43m
    $306–441

Santa Ana to Columbia by train, foot, and bus

Calendar7Weekly Services
Duration39h 54mAverage Duration
Ticket$576Cheapest Price
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Questions & Answers

Map of how to get from Santa Ana to Columbia.ExpandLaunch map view
  • Distance: 1,485.2 mi
  • Duration: 6h 15m

What companies run services between Santa Ana, CA, USA and Columbia, MO, USA?

United Airlines, American Airlines, and Southwest Airlines fly from John Wayne Airport Orange County (SNA) to Columbia Regional Airport (COU) every 4 hours. Alternatively, you can take a bus from Santa Ana Bus Stop to Columbia via Los Angeles Union Station and St Louis Bus Station in around 47h.

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