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How to get fromSanta Ana to Des Moinesby plane, bus (Greyhound), train, bus, or car

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There are 4 ways to get from Santa Ana to Des Moines by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Des Moines (DSM)plane plane SNA - DSM
    3h 38m
    $255–954

  2. Bus (Greyhound)

    1. Take the bus from Santa Ana Bus Stop to Las Vegas Bus Terminalbus bus
    2. Take the bus from Las Vegas Bus Terminal to Denver Union Stationbus bus
    3. Take the bus from Denver Union Station to Des Moinesbus bus
    36h 55m
    $263–520

  3. Train, bus

    1. Take the train from Fullerton Amtrak Station to Kansas Citytrain train Southwest Chief
    2. Take the bus from Kansas City to Des Moinesbus bus Jefferson 802 / ...
    40h 33m
    $607–1,284

  4. Drive 1,679.8 mi

    1. Drive from Santa Ana to Des Moinescar car 1,679.8 mi
    26h 2m
    $307–443

Santa Ana to Des Moines by bus (Greyhound)

Calendar7Weekly Buses
Duration36h 55mAverage Duration
Ticket$263Cheapest Price
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Questions & Answers

Map of how to get from Santa Ana to Des Moines.ExpandLaunch map view
  • Distance: 1,437.9 mi
  • Duration: 3h 38m

What companies run services between Santa Ana, CA, USA and Des Moines, IA, USA?

Allegiant Air, Southwest Airlines, and three other airlines fly from John Wayne Airport Orange County (SNA) to Des Moines (DSM) every 4 hours. Alternatively, you can take a bus from Santa Ana Bus Stop to Des Moines via Las Vegas Bus Terminal and Denver Union Station in around 36h 55m.

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