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How to get fromSanta Ana to Key Westby plane, train, bus, ferry, or car

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There are 9 ways to get from Santa Ana to Key West by plane, train, bus, ferry, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Wayne Airport Orange County

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Key West International Airport (EYW)plane plane SNA - EYW
    7h 39m
    $169–646

  2. Train to San Diego International Airport, fly

    cheapest
    1. Take the train from Santa Ana to San Diego Old Town Transportation Centertrain train
    2. Fly from San Diego International Airport (SAN) to Key West International Airport (EYW)plane plane SAN - EYW
    10h 20m
    $133–505

  3. Train, bus, ferry via Irving

    1. Take the train from Santa Ana to L.A. Union Stationtrain train
    2. Take the bus from Los Angeles Union Station to Dallas Bus Stationbus bus
    3. Take the bus from Dallas Bus Station to Houston Bus Stationbus bus
    4. Take the bus from Houston - Harrisburg Blvd to Fort Myersbus bus
    5. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    2d 15h
    $608–846

  4. Train, bus, ferry

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Take the train from Los Angeles to New Orleans Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    4. Take the bus from Gulfport to Fort Myersbus bus
    5. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    2d 21h
    $810–1,600

  5. Drive  2,815.8 mi

    1. Drive from Santa Ana to Key Westcar car 2,815.8 mi
    47h 10m
    $514–743

  6. Train to Los Angeles International Airport, fly

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Fly from Los Angeles International Airport (LAX) to Key West International Airport (EYW)plane plane LAX - EYW
    10h 8m
    $137–506

  7. Train to Burbank Bob Hope Airport, fly

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Fly from Burbank Bob Hope Airport (BUR) to Key West International Airport (EYW)plane plane BUR - EYW
    22h 14m
    $136–533

  8. Train, train to Ontario International Airport, fly

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Take the train from Los Angeles to Ontario Amtraktrain train
    3. Fly from Ontario International Airport (ONT) to Key West International Airport (EYW)plane plane ONT - EYW
    11h 29m
    $151–607

  9. Train, bus

    1. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus
    4d 2h
    $1,048–2,572

Santa Ana to Key West by train, taxi, bus, and foot

Calendar7Weekly Services
Duration4d 2hAverage Duration
Ticket$1,048Cheapest Price
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Comparing Your Travel Options

Map of how to get from Santa Ana to Key West.ExpandLaunch map view
  • Distance: 2,263.5 mi
  • Duration: 7h 39m

What companies run services between Santa Ana, CA, USA and Key West, FL, USA?

Delta and United Airlines fly from John Wayne Airport Orange County (SNA) to Key West International Airport (EYW) twice daily.

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Train operators
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