There are 5 ways to get from Santa Ana to Klamath Falls by plane, bus, bus (Greyhound), train (Amtrak), car, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from John Wayne Airport Orange County, bus
best- Fly from John Wayne Airport Orange County (SNA) to Rogue Valley International - Medford Airport (MFR)plane SNA - MFR
- Take the bus from Medford Airport to Klamath Falls Amtrak Stationbus
4h 46m$269–548Bus
cheapest- Take the bus from Santa Ana Bus Stop to Sacramento Bus Stationbus
- Take the bus from Sacramento Bus Station to Redding Bus Stationbus
- Take the bus from Redding Area Bus Authority - to Corner Of Main And West Fifth Avebus
- Take the bus from Corner Of Main And West Fifth Ave to Greyhound Connection To Medford Via The Shuttle Klamath Falls + Amtrak Klamath Falls Rail Stationbus
22h 10m$131–201Train (Amtrak)
- Take the train from Santa Ana to Los Angelestrain Pacific Surfliner
- Take the train from Los Angeles to Klamath Fallstrain Coast Starlight
23h 35m$219–520Drive 714.6 mi
- Drive from Santa Ana to Klamath Fallscar 714.6 mi
12h 7m$131–189Train to Los Angeles International Airport, fly, bus
- Take the train from Santa Ana to Los Angelestrain
- Fly from Los Angeles International Airport (LAX) to Rogue Valley International - Medford Airport (MFR)plane LAX - MFR
- Take the bus from Medford Airport to Klamath Falls Amtrak Stationbus
7h 38m$167–478
Santa Ana to Klamath Falls by bus
Comparing Your Travel Options
The cheapest way to get from Santa Ana to Klamath Falls is to bus which costs $130 - $210 and takes 22h 10m.
The fastest way to get from Santa Ana to Klamath Falls is to fly and bus which takes 4h 46m and costs $260 - $550.
No, there is no direct bus from Santa Ana to Klamath Falls station. However, there are services departing from Santa Ana Bus Stop and arriving at Greyhound Connection To Medford Via The Shuttle Klamath Falls + Amtrak Klamath Falls Rail Station via Sacramento Bus Station, Redding Area Bus Authority - and Corner Of Main And West Fifth Ave. The journey, including transfers, takes approximately 22h 10m.
No, there is no direct train from Santa Ana to Klamath Falls. However, there are services departing from Santa Ana and arriving at Klamath Falls via Los Angeles. The journey, including transfers, takes approximately 23h 35m.
The distance between Santa Ana and Klamath Falls is 745 miles. The road distance is 718.7 miles.
The best way to get from Santa Ana to Klamath Falls without a car is to bus which takes 22h 10m and costs $130 - $210.
It takes approximately 4h 46m to get from Santa Ana to Klamath Falls, including transfers.
Santa Ana to Klamath Falls bus services, operated by Greyhound USA, depart from Santa Ana Bus Stop station.
Santa Ana to Klamath Falls train services, operated by Amtrak, depart from Santa Ana station.
The best way to get from Santa Ana to Klamath Falls is to bus which takes 22h 10m and costs $130 - $210. Alternatively, you can train, which costs $210 - $550 and takes 23h 35m.
What companies run services between Santa Ana, CA, USA and Klamath Falls, OR, USA?
You can take a bus from Santa Ana Bus Stop to Greyhound Connection To Medford Via The Shuttle Klamath Falls + Amtrak Klamath Falls Rail Station via Sacramento Bus Station, Redding Area Bus Authority -, and Corner Of Main And West Fifth Ave in around 22h 10m. Alternatively, you can take a train from Santa Ana to Klamath Falls via Los Angeles in around 23h 35m.
- Website
- alaskaair.com
Flights from John Wayne Airport Orange County to Rogue Valley International - Medford Airport via Portland
- Ave. Duration
- 4h 39m
- When
- Every day
- Estimated price
- $230–470
Flights from Los Angeles International Airport to Rogue Valley International - Medford Airport
- Ave. Duration
- 2h 7m
- When
- Every day
- Estimated price
- $140–400
Flights from Los Angeles International Airport to Rogue Valley International - Medford Airport via Portland
- Ave. Duration
- 4h 48m
- When
- Every day
- Estimated price
- $140–400
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Santa Ana to Los Angeles
- Ave. Duration
- 53 min
- Frequency
- Hourly
- Estimated price
- $8–20
- Website
- Amtrak
Train from Los Angeles to Klamath Falls
- Ave. Duration
- 21h 42m
- Frequency
- Once daily
- Estimated price
- $210–500
- Website
- Amtrak
Train from Santa Ana to Los Angeles
- Ave. Duration
- 53 min
- Frequency
- Hourly
- Estimated price
- $8–20
- Website
- Amtrak
- Phone
- +1 888-846-4183
- Website
- Point
Bus from Medford Airport to Klamath Falls Amtrak Station
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Estimated price
- $11–29
- Website
- Point
Bus from Medford Airport to Klamath Falls Amtrak Station
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Estimated price
- $11–29
- Website
- Point
Want to know more about travelling around United States
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Booking & Getting There
Santa Ana to Klamath Falls bus services, operated by Greyhound USA, arrive at Sacramento Bus Station.
Santa Ana to Klamath Falls train services, operated by Amtrak, arrive at Los Angeles station.
Yes, the driving distance between Santa Ana to Klamath Falls is 719 miles. It takes approximately 12h 7m to drive from Santa Ana to Klamath Falls.
Book your Santa Ana to Klamath Falls train tickets online with Omio.
There are 71+ hotels available in Klamath Falls.








