There are 4 ways to get from Santa Ana to La Mesa by bus, tram, train (Amtrak), car, or bus (Greyhound, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, tram
best- Take the bus from Santa Ana to San Diegobus Los Angeles
- Take the tram from 12th & Imperial Station to La Mesa Blvd Stationtram Orange
2h 24m$21–42Drive 91.9 mi
cheapest- Drive from Santa Ana to La Mesacar 91.9 mi
1h 37m$17–25Train (Amtrak)
- Take the train from Santa Ana to San Diego Old Town Transportation Centertrain Pacific Surfliner
2h 27m$31–73Bus, line 10 bus
- Take the bus from Santa Ana Bus Stop to San Diego Greyhound Bus Stopbus Greyhound US0831
- Take the bus from Old Town Transit Center to University Av & College Avbus 10
3h 24m$17–35
Santa Ana to La Mesa by bus and tram
Questions & Answers
The cheapest way to get from Santa Ana to La Mesa is to drive which costs $16 - $25 and takes 1h 37m.
The fastest way to get from Santa Ana to La Mesa is to drive which takes 1h 37m and costs $16 - $25.
No, there is no direct bus from Santa Ana to La Mesa. However, there are services departing from Santa Ana Bus Stop and arriving at University Av & Allison Av via Old Town Transit Center and University Av & College Av. The journey, including transfers, takes approximately 3h 24m.
No, there is no direct train from Santa Ana to La Mesa station. However, there are services departing from Santa Ana and arriving at 70th Street Station via Old Town Station. The journey, including transfers, takes approximately 2h 27m.
The distance between Santa Ana and La Mesa is 102 miles. The road distance is 92.4 miles.
The best way to get from Santa Ana to La Mesa without a car is to bus and tram which takes 2h 24m and costs $20 - $45.
It takes approximately 2h 24m to get from Santa Ana to La Mesa, including transfers.
Santa Ana to La Mesa bus services, operated by Greyhound-us, depart from Santa Ana Bus Stop station.
Santa Ana to La Mesa train services, operated by Amtrak, depart from Santa Ana station.
The best way to get from Santa Ana to La Mesa is to train which takes 2h 27m and costs $30 - $75. Alternatively, you can bus and line 10 bus, which costs $17 - $35 and takes 3h 24m.
What companies run services between Santa Ana, CA, USA and La Mesa, CA, USA?
Amtrak operates a train from Santa Ana to San Diego Old Town Transportation Center hourly. Tickets cost $29–60 and the journey takes 1h 51m. Alternatively, you can take a bus from Santa Ana Bus Stop to University Av & Allison Av via San Diego Greyhound Bus Stop, Old Town Transit Center, and University Av & College Av in around 3h 24m.
- Phone
- +1 619-557-4555
- Website
- sdmts.com
Tram from 12th & Imperial Station to La Mesa Blvd Station
- Ave. Duration
- 29 min
- Frequency
- Every 20 minutes
- Estimated price
- $2–14
- Website
- https://www.sdmts.com
- Schedules at
- https://www.sdmts.com/getting-around/departures-and-schedules
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Santa Ana to San Diego Old Town Transportation Center
- Ave. Duration
- 1h 51m
- Frequency
- Hourly
- Estimated price
- $29–60
- Website
- https://www.amtrak.com/home.html
- Phone
- +1-800-231-2222
- [email protected]
- Website
- greyhound.com.mx
Bus from Santa Ana to San Diego
- Ave. Duration
- 1h 45m
- Frequency
- 3 times a day
- Estimated price
- $18–28
- Schedules at
- greyhound.com.mx
- Website
- greyhound.com
Bus from Santa Ana Bus Stop to San Diego Greyhound Bus Stop
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Schedules at
- greyhound.com
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Santa Ana Bus Stop to San Diego Greyhound Bus Stop
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $13–25
- Website
- https://www.greyhound.com/
- Website
- flixbus.com
Bus from Santa Ana Bus Stop to San Diego Greyhound Bus Stop
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Schedules at
- flixbus.com
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Santa Ana Bus Stop to San Diego Greyhound Bus Stop
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Estimated price
- $14–24
- Schedules at
- flixbus.com
- Phone
- +1 619-557-4555
- Website
- sdmts.com
Bus from Old Town Transit Center to University Av & College Av
- Ave. Duration
- 50 min
- Frequency
- Every 30 minutes
- Estimated price
- $2–5
- Website
- https://www.sdmts.com
- Schedules at
- https://www.sdmts.com/getting-around/departures-and-schedules
- One Way - Adult/Youth
- $2–5
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More Questions & Answers
Santa Ana to La Mesa bus services, operated by Greyhound-us, arrive at San Diego Greyhound Bus Stop station.
Santa Ana to La Mesa train services, operated by Amtrak, arrive at San Diego Old Town Transportation Center station.
Yes, the driving distance between Santa Ana to La Mesa is 92 miles. It takes approximately 1h 37m to drive from Santa Ana to La Mesa.
There are 2191+ hotels available in La Mesa.















