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How to get fromSanta Ana to Louisvilleby plane, bus (Greyhound), train, bus, or car

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There are 6 ways to get from Santa Ana to Louisville by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Wayne Airport Orange County

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Louisville International Airport (SDF)plane plane SNA - SDF
    7h 9m
    $249–936

  2. Bus

    1. Take the bus from Santa Ana Bus Stop to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    4. Take the bus from Evansville, IN to Louisville, KYbus bus
    2d 2h
    $369–719

  3. Train, bus via Chicago (Amtrak)

    1. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    2d 5h
    $789–1,684

  4. Drive 2,064.8 mi

    1. Drive from Santa Ana to Louisvillecar car 2,064.8 mi
    32h 59m
    $377–545

  5. Train to Los Angeles International Airport, fly

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Fly from Los Angeles International Airport (LAX) to Louisville International Airport (SDF)plane plane LAX - SDF
    10h 3m
    $379–889

  6. Train, bus

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Take the train from Los Angeles to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    4. Take the bus from Evansville, IN to Louisville, KYbus bus
    2d 17h
    $872–1,728

Santa Ana to Louisville by bus

Calendar7Weekly Buses
Duration2d 2hAverage Duration
Ticket$369Cheapest Price
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Questions & Answers

Map of how to get from Santa Ana to Louisville.ExpandLaunch map view
  • Distance: 1,825.9 mi
  • Duration: 7h 9m

What companies run services between Santa Ana, CA, USA and Louisville, KY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from John Wayne Airport Orange County (SNA) to Louisville International Airport (SDF) every 3 hours. Alternatively, you can take a bus from Santa Ana Bus Stop to Louisville, KY via Los Angeles Union Station, St Louis Bus Station, and Evansville, IN in around 2d 2h.

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