There are 6 ways to get from Santa Ana to Main Street @ 1st Avenue by bus (Flixbus, Greyhound), train (Amtrak), car, plane, bus (Greyhound), train, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus via Mexicali
best- Take the bus from Santa Ana Bus Stop to San Ysidro Bus Terminalbus
- Take the bus from Tijuana to Mexicalibus
- Take the bus from Mexicali to San Luis Río Coloradobus
8h 22m$43–132Bus
cheapest- Take the bus from Santa Ana to Tijuana - Plaza El Mexicanobus Los Angeles
- Take the bus from Tijuana to San Luis Río Coloradobus
9h 46m$42–101Train (Amtrak)
- Take the train from Santa Ana to Los Angelestrain Pacific Surfliner
- Take the train from Los Angeles to Yuma Amtraktrain Texas Eagle / ...
8h 28m$87–195Drive 246.8 mi
- Drive from Santa Ana to Main Street @ 1st Avenuecar 246.8 mi
4h 50m$45–66Fly John Wayne Airport Orange County to Yuma International Airport
- Fly from John Wayne Airport Orange County (SNA) to Yuma International Airport (YUM)plane SNA - YUM
5h 45m$90–387Train to Los Angeles International Airport, fly to Imperial County Airport, bus
- Take the train from Santa Ana to Los Angelestrain
- Fly from Los Angeles International Airport (LAX) to Imperial County Airport (IPL)plane LAX - IPL
- Take the bus from Mexicali to San Luis Río Coloradobus
7h 34m$112–543
Santa Ana to Main Street @ 1st Avenue by train and bus (Amtrak)
Questions & Answers
The cheapest way to get from Santa Ana to Main Street @ 1st Avenue is to drive which costs $45 - $65 and takes 4h 50m.
The fastest way to get from Santa Ana to Main Street @ 1st Avenue is to drive which takes 4h 50m and costs $45 - $65.
No, there is no direct bus from Santa Ana to Main Street @ 1st Avenue. However, there are services departing from Santa Ana Bus Stop and arriving at Main Street @ 1st Avenue via Tijuana, Mexicali and William Brook Ave @ B Street. The journey, including transfers, takes approximately 8h 22m.
No, there is no direct train from Santa Ana to Main Street @ 1st Avenue. However, there are services departing from Santa Ana and arriving at Yuma Amtrak via Los Angeles. The journey, including transfers, takes approximately 8h 28m.
The distance between Santa Ana and Main Street @ 1st Avenue is 267 miles. The road distance is 248.3 miles.
The best way to get from Santa Ana to Main Street @ 1st Avenue without a car is to bus via Mexicali which takes 8h 22m and costs $40 - $140.
It takes approximately 8h 22m to get from Santa Ana to Main Street @ 1st Avenue, including transfers.
Santa Ana to Main Street @ 1st Avenue bus services, operated by Flixbus USA, depart from Santa Ana Bus Stop station.
Santa Ana to Main Street @ 1st Avenue train services, operated by Amtrak, depart from Santa Ana station.
The best way to get from Santa Ana to Main Street @ 1st Avenue is to bus via Mexicali which takes 8h 22m and costs $40 - $140. Alternatively, you can train, which costs $85 - $200 and takes 8h 28m, you could also fly, which costs $85 - $390 and takes 5h 45m.
What companies run services between Santa Ana, CA, USA and Main Street @ 1st Avenue, AZ, USA?
You can take a bus from Santa Ana Bus Stop to Main Street @ 1st Avenue via San Ysidro Bus Terminal, Tijuana, Mexicali, San Luis Río Colorado, and William Brook Ave @ B Street in around 8h 22m. Alternatively, you can take a train from Santa Ana to Main Street Gadsen @ 1st Avenue via Los Angeles, Yuma Amtrak, and 3rd Street @ Gila Street in around 8h 28m.
- Website
- aa.com
Flights from John Wayne Airport Orange County to Yuma International Airport via Phoenix
- Ave. Duration
- 4h 3m
- When
- Every day
- Estimated price
- $60–350
- Website
- iflysouthern.com
Flights from Los Angeles International Airport to Imperial County Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- $80–230
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Santa Ana to Los Angeles
- Ave. Duration
- 53 min
- Frequency
- Hourly
- Estimated price
- $11–23
- Website
- Amtrak
Train from Los Angeles to Yuma Amtrak
- Ave. Duration
- 4h 47m
- Frequency
- 6 times a week
- Estimated price
- $75–170
- Website
- Amtrak
Train from Santa Ana to Los Angeles
- Ave. Duration
- 53 min
- Frequency
- Hourly
- Estimated price
- $11–23
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Santa Ana Bus Stop to San Ysidro Bus Terminal
- Ave. Duration
- 2h 15m
- Frequency
- 4 times a day
- Estimated price
- $16–28
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Santa Ana Bus Stop to San Ysidro Bus Terminal
- Ave. Duration
- 2h 20m
- Frequency
- 4 times a day
- Estimated price
- $16–30
- Website
- Greyhound
- Phone
- +52 664 104 7400
- [email protected]
- Website
- abc.com.mx
Bus from Tijuana to Mexicali
- Ave. Duration
- 2h 5m
- Frequency
- Every 3 hours
- Estimated price
- $21–40
- Schedules at
- abc.com.mx
- Book at
- abc.com.mx
Bus from Mexicali to San Luis Río Colorado
- Ave. Duration
- 1h 30m
- Frequency
- 5 times a day
- Estimated price
- $8–19
- Schedules at
- abc.com.mx
- Book at
- abc.com.mx
Bus from Mexicali to San Luis Río Colorado
- Ave. Duration
- 1h 30m
- Frequency
- 5 times a day
- Estimated price
- $8–19
- Schedules at
- abc.com.mx
- Book at
- abc.com.mx
- Phone
- +52 55 5141 4300
- [email protected]
- Website
- odm.com.mx
Bus from Mexicali to San Luis Río Colorado
- Ave. Duration
- 1h 20m
- Frequency
- Every 30 minutes
- Estimated price
- $23–35
- Schedules at
- odm.com.mx
- Book at
- odm.com.mx
Bus from Tijuana to San Luis Río Colorado
- Ave. Duration
- 4h
- Frequency
- Every 30 minutes
- Estimated price
- $40–60
- Schedules at
- odm.com.mx
- Book at
- odm.com.mx
Bus from Mexicali to San Luis Río Colorado
- Ave. Duration
- 1h 20m
- Frequency
- Every 30 minutes
- Estimated price
- $23–35
- Schedules at
- odm.com.mx
- Book at
- odm.com.mx
- Phone
- +52 55 4440 3187
- [email protected]
- Website
- autobuseselite.com.mx
Bus from Mexicali to San Luis Río Colorado
- Ave. Duration
- 1h 20m
- Frequency
- 5 times a day
- Estimated price
- $17–26
- Schedules at
- autobuseselite.com.mx
- Book at
- autobuseselite.com.mx
Bus from Tijuana to San Luis Río Colorado
- Ave. Duration
- 4h 7m
- Frequency
- 5 times a day
- Estimated price
- $30–50
- Schedules at
- autobuseselite.com.mx
- Book at
- autobuseselite.com.mx
Bus from Mexicali to San Luis Río Colorado
- Ave. Duration
- 1h 20m
- Frequency
- 5 times a day
- Estimated price
- $17–26
- Schedules at
- autobuseselite.com.mx
- Book at
- autobuseselite.com.mx
- Phone
- +52 644 410 2444
- [email protected]
- Website
- tufesa.com.mx
Bus from Mexicali to San Luis Río Colorado
- Ave. Duration
- 1h 30m
- Frequency
- Every 4 hours
- Estimated price
- $5–20
- Schedules at
- tufesa.com.mx
- Book at
- tufesa.com.mx
- Plus
- $5–20
- Titanium
- $6–19
Bus from Tijuana to San Luis Río Colorado
- Ave. Duration
- 4h
- Frequency
- Every 4 hours
- Estimated price
- $19–35
- Schedules at
- tufesa.com.mx
- Book at
- tufesa.com.mx
- Plus
- $19–35
- Titanium
- $21–35
Bus from Mexicali to San Luis Río Colorado
- Ave. Duration
- 1h 30m
- Frequency
- Every 4 hours
- Estimated price
- $5–20
- Schedules at
- tufesa.com.mx
- Book at
- tufesa.com.mx
- Plus
- $5–20
- Titanium
- $6–19
- Phone
- +52 55 4440 3187
- [email protected]
- Website
- chihuahuenses.com.mx
Bus from Mexicali to San Luis Río Colorado
- Ave. Duration
- 1h 5m
- Frequency
- Twice daily
- Estimated price
- $15–22
- Schedules at
- chihuahuenses.com.mx
- Book at
- chihuahuenses.com.mx
Bus from Tijuana to San Luis Río Colorado
- Ave. Duration
- 3h 25m
- Frequency
- Twice daily
- Estimated price
- $35–55
- Schedules at
- chihuahuenses.com.mx
- Book at
- chihuahuenses.com.mx
Bus from Mexicali to San Luis Río Colorado
- Ave. Duration
- 1h 5m
- Frequency
- Twice daily
- Estimated price
- $15–22
- Schedules at
- chihuahuenses.com.mx
- Book at
- chihuahuenses.com.mx
- Phone
- +52 664 299 0487
- [email protected]
- Website
- acnautobuses.com
Bus from Mexicali to San Luis Río Colorado
- Ave. Duration
- 1h
- Frequency
- Once daily
- Estimated price
- $40–60
- Schedules at
- acnautobuses.com
- Book at
- acnautobuses.com
Bus from Tijuana to San Luis Río Colorado
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $40–65
- Schedules at
- acnautobuses.com
- Book at
- acnautobuses.com
Bus from Mexicali to San Luis Río Colorado
- Ave. Duration
- 1h
- Frequency
- Once daily
- Estimated price
- $40–60
- Schedules at
- acnautobuses.com
- Book at
- acnautobuses.com
- Phone
- +1-800-231-2222
- [email protected]
- Website
- Greyhound Mexico
Bus from Santa Ana to Tijuana - Plaza El Mexicano
- Ave. Duration
- 4h
- Frequency
- 3 times a day
- Estimated price
- $22–35
- Schedules at
- Greyhound Mexico
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More Questions & Answers
Santa Ana to Main Street @ 1st Avenue bus services, operated by Flixbus USA, arrive at San Ysidro Bus Terminal station.
Santa Ana to Main Street @ 1st Avenue train services, operated by Amtrak, arrive at Los Angeles station.
Yes, the driving distance between Santa Ana to Main Street @ 1st Avenue is 248 miles. It takes approximately 4h 50m to drive from Santa Ana to Main Street @ 1st Avenue.
There are 14+ hotels available in Main Street @ 1st Avenue.






































