There are 7 ways to get from Santa Ana to Mesa by plane, tram, train, bus, taxi, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly, tram
best- Fly from John Wayne Airport Orange County (SNA) to Phoenix (PHX)plane SNA - PHX
- Take the tram from 44th St/Washington to Mesa Dr/Main Sttram
2h 20m$90–585Bus
cheapest- Take the bus from ABC Supermarket - Westminster, CA to Lee's Sandwiches - Chandler, AZbus Southern CA
10h 29m$49–64Train, bus via San Bernardino
- Take the train from Santa Ana to San Bernardino - Downtowntrain IE-OC Line
- Take the bus from San Bernardino to Phoenixbus Lxus 2224 / ...
8h 26m$61–90Train, taxi (Amtrak)
- Take the train from Santa Ana to Los Angelestrain
- Take the train from Los Angeles to Maricopa Amtraktrain
- Take the taxi from Maricopa Amtrak to Mesataxi
10h 12m$194–370Drive 371.6 mi
- Drive from Santa Ana to Mesacar 371.6 mi
6h 5m$68–98Bus via 24th St/Jefferson
- Take the bus from Santa Ana to Phoenixbus Cbx
10h 28m$67–92Train, bus
- Take the train from Santa Ana to L.A. Union Stationtrain OC Line
- Take the bus from Los Angeles Union Station to Phoenix Sky Harbor Airport/44th Street Sky Train Stationbus FlixBus 2054
12h 48m$80–123
Santa Ana to Mesa by train, foot, bus, and tram
Comparing Your Travel Options
The cheapest way to get from Santa Ana to Mesa is to bus which costs $45 - $65 and takes 10h 29m.
The fastest way to get from Santa Ana to Mesa is to fly and tram which takes 2h 20m and costs $85 - $600.
No, there is no direct bus from Santa Ana to Mesa. However, there are services departing from Santa Ana and arriving at Phoenix via . The journey, including transfers, takes approximately 10h 28m.
The distance between Santa Ana and Mesa is 358 miles. The road distance is 373.8 miles.
The best way to get from Santa Ana to Mesa without a car is to train and bus via San Bernardino which takes 8h 26m and costs $60 - $90.
It takes approximately 2h 20m to get from Santa Ana to Mesa, including transfers.
Santa Ana to Mesa bus services, operated by CBX Cross Border Express, depart from Santa Ana station.
Santa Ana to Mesa bus services, operated by CBX Cross Border Express, arrive at Phoenix station.
Yes, the driving distance between Santa Ana to Mesa is 374 miles. It takes approximately 6h 5m to drive from Santa Ana to Mesa.
Book your Santa Ana to Mesa bus tickets online with Omio.
What companies run services between Santa Ana, CA, USA and Mesa, AZ, USA?
CBX Cross Border Express operates a bus from Santa Ana to Phoenix twice daily. Tickets cost $65–95 and the journey takes 9h 30m.
- Website
- southwest.com
Flights from John Wayne Airport Orange County to Phoenix
- Ave. Duration
- 1h 17m
- When
- Every day
- Estimated price
- $40–280
- Phone
- +1 (602) 253-5000
- [email protected]
- Website
- Valley Metro
Tram from 44th St/Washington to Mesa Dr/Main St
- Ave. Duration
- 41 min
- Frequency
- Every 20 minutes
- Estimated price
- $2
- Website
- Valley Metro
- Phone
- +1 866 691 9732
- [email protected]
- Website
- Limousine Express
Bus from San Bernardino to Phoenix
- Ave. Duration
- 4h 50m
- Frequency
- 5 times a day
- Estimated price
- $50–75
- Website
- Limousine Express
- One Way
- $50–75
- Ave. Duration
- 44 min
- Estimated price
- $85–110
Want to know more about travelling around United States
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Booking & Getting There
There are 2761+ hotels available in Mesa.




