There are 7 ways to get from Santa Ana to Mesquite by plane, shuttle, bus, train, car, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from John Wayne Airport Orange County, shuttle
best- Fly from John Wayne Airport Orange County (SNA) to Harry Reid International Airport (LAS)plane SNA - LAS
- Take a shuttle bus from Harry Reid International to Mesquite, NV - Eureka Casino
3h 32m$158–628Drive 345.7 mi
cheapest- Drive from Santa Ana to Mesquitecar 345.7 mi
5h 37m$64–92Bus
- Take the bus from Santa Ana to Huntington Parkbus 2
- Take the bus from Huntington Park to Las Vegasbus
- Take the bus from Las Vegas to Mesquite, NVbus
9h 40m$108–179Train, bus
- Take the train from Fullerton Amtrak Station to Kingman Stationtrain
- Take the bus from Kingman, AZ to Las Vegasbus
- Take the bus from Las Vegas to Mesquite, NVbus
13h 1m$182–364Train to Los Angeles International Airport, fly, shuttle
- Take the train from Santa Ana to Los Angelestrain
- Fly from Los Angeles International Airport (LAX) to Harry Reid International Airport (LAS)plane LAX - LAS
- Take a shuttle bus from Harry Reid International to Mesquite, NV - Eureka Casino
6h 16m$148–981Bus via San Bernardino
- Take the bus from Katella + Harbor to San Bernardinobus 200
- Take the bus from San Bernardino to SB Las Vegas at Fashion Show Mallbus
- Take the bus from Harry Reid International to Mesquite, NVbus
11h 51m$74–111Bus #2
- Take the bus from Anaheim Regional Transportation Intermodal Center to Las Vegas Stripbus FlixBus 2037
- Take the bus from Harry Reid International to Mesquite, NVbus Las Vegas
12h 24m$78–146
Santa Ana to Mesquite by bus
Questions & Answers
The cheapest way to get from Santa Ana to Mesquite is to drive which costs $60 - $95 and takes 5h 37m.
The fastest way to get from Santa Ana to Mesquite is to fly and shuttle which takes 3h 32m and costs $150 - $650.
No, there is no direct bus from Santa Ana to Mesquite. However, there are services departing from Santa Ana and arriving at Mesquite, NV via Huntington Park and Las Vegas. The journey, including transfers, takes approximately 9h 40m.
The distance between Santa Ana and Mesquite is 321 miles. The road distance is 347.7 miles.
The best way to get from Santa Ana to Mesquite without a car is to bus which takes 9h 40m and costs $100 - $180.
It takes approximately 3h 32m to get from Santa Ana to Mesquite, including transfers.
Santa Ana to Mesquite bus services, operated by Limousine Express, depart from Santa Ana station.
Santa Ana to Mesquite bus services, operated by Limousine Express, arrive at Huntington Park station.
Yes, the driving distance between Santa Ana to Mesquite is 348 miles. It takes approximately 5h 37m to drive from Santa Ana to Mesquite.
There are 43+ hotels available in Mesquite.
What companies run services between Santa Ana, CA, USA and Mesquite, NV, USA?
You can take a bus from Santa Ana to Mesquite, NV via Huntington Park and Las Vegas in around 9h 40m.
- Website
- southwest.com
Flights from John Wayne Airport Orange County to Harry Reid International Airport
- Ave. Duration
- 1h 13m
- When
- Every day
- Estimated price
- $40–290
Flights from Los Angeles International Airport to Harry Reid International Airport
- Ave. Duration
- 1h 13m
- When
- Every day
- Estimated price
- $35–270
- Website
- united.com
Flights from Los Angeles International Airport to Harry Reid International Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- $35–270
- Website
- jsx.com
Flights from John Wayne Airport Orange County to Harry Reid International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- $40–290
Flights from Los Angeles International Airport to Harry Reid International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- $35–270
- Website
- delta.com
Flights from John Wayne Airport Orange County to Harry Reid International Airport
- Ave. Duration
- 1h 19m
- When
- Every day
- Estimated price
- $40–290
Flights from Los Angeles International Airport to Harry Reid International Airport
- Ave. Duration
- 1h 12m
- When
- Every day
- Estimated price
- $35–270
- Website
- aa.com
Flights from Los Angeles International Airport to Harry Reid International Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- $35–270
- Website
- flyfrontier.com
Flights from John Wayne Airport Orange County to Harry Reid International Airport
- Ave. Duration
- 1h 11m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $85–230
Flights from Los Angeles International Airport to Harry Reid International Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- $85–190
- Website
- flybreeze.com
Flights from John Wayne Airport Orange County to Harry Reid International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- $110–600
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Fullerton Amtrak Station to Kingman Station
- Ave. Duration
- 6h 50m
- Frequency
- Once daily
- Estimated price
- $110–240
- Website
- Amtrak
Train from Santa Ana to Los Angeles
- Ave. Duration
- 53 min
- Frequency
- Hourly
- Estimated price
- $11–23
- Website
- Amtrak
- Phone
- +1 800-933-8320
- [email protected]
- Website
- St. George Shuttle
Shuttle from Harry Reid International to Mesquite, NV - Eureka Casino
- Ave. Duration
- 1h 20m
- Frequency
- Hourly
- Estimated price
- $30–45
- Website
- St. George Shuttle
Shuttle from Harry Reid International to Mesquite, NV - Eureka Casino
- Ave. Duration
- 1h 20m
- Frequency
- Hourly
- Estimated price
- $30–45
- Website
- St. George Shuttle
- Phone
- +1 866 691 9732
- [email protected]
- Website
- Limousine Express
Bus from Santa Ana to Huntington Park
- Ave. Duration
- 1h
- Frequency
- Every 3 hours
- Estimated price
- $24–35
- Website
- Limousine Express
- One Way
- $24–35
- [email protected]
- Website
- CBX Cross Border Express
Bus from Santa Ana to Huntington Park
- Ave. Duration
- 1h 5m
- Frequency
- Twice daily
- Estimated price
- $17–25
- Schedules at
- CBX Cross Border Express
- Phone
- +1 833 766 3553
- Website
- Tufesa
Bus from Huntington Park to Las Vegas
- Ave. Duration
- 5h 30m
- Frequency
- Twice daily
- Estimated price
- $60–90
- Schedules at
- Tufesa
- Adult One way
- $60–90
Bus from Las Vegas to Mesquite, NV
- Ave. Duration
- 1h 10m
- Frequency
- Once daily
- Estimated price
- $30–55
- Schedules at
- Tufesa
- Adult One way
- $30–55
Bus from Kingman, AZ to Las Vegas
- Ave. Duration
- 1h 25m
- Frequency
- Every 3 hours
- Estimated price
- $35–60
- Schedules at
- Tufesa
- Adult One way
- $35–60
Bus from Las Vegas to Mesquite, NV
- Ave. Duration
- 1h 10m
- Frequency
- Once daily
- Estimated price
- $30–55
- Schedules at
- Tufesa
- Adult One way
- $30–55
- Phone
- +1 (951) 565-5002
- Website
- Riverside Transit Agency
Bus from Katella + Harbor to San Bernardino
- Ave. Duration
- 1h 57m
- Frequency
- Hourly
- Estimated price
- $1–5
- Website
- Riverside Transit Agency
- Children 46" tall and under
- $1–4
- Seniors 60+, Disabled, Medicare
- $1–4
- Adults and children over 46" tall
- $1–5
- Phone
- +1 602-698-7800
- [email protected]
- Website
- Luxury Coach of America
Bus from San Bernardino to SB Las Vegas at Fashion Show Mall
- Ave. Duration
- 4h 29m
- Frequency
- 5 times a week
- Estimated price
- $45
- Schedules at
- Luxury Coach of America
- Phone
- +1 208-656-8824
- [email protected]
- Website
- Salt Lake Express
Bus from Harry Reid International to Mesquite, NV
- Ave. Duration
- 1h 26m
- Frequency
- Every 3 hours
- Estimated price
- $22–55
- Website
- Salt Lake Express
Bus from Harry Reid International to Mesquite, NV
- Ave. Duration
- 1h 26m
- Frequency
- Every 3 hours
- Estimated price
- $22–55
- Website
- Salt Lake Express
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Anaheim Regional Transportation Intermodal Center to Las Vegas Strip
- Ave. Duration
- 7h 15m
- Frequency
- Twice daily
- Estimated price
- $50–85
- Schedules at
- Flixbus USA
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