There are 6 ways to get from Santa Ana to Mexicali by bus (Flixbus, Greyhound), train, bus, car, plane, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus via Tijuana
best- Take the bus from Santa Ana to San Ysidrobus Lxus 3105 / ...
- Take the bus from Tijuana to Mexicalibus
5h 7m$649–1,161Bus
cheapest- Take the bus from Santa Ana to Tijuana - Plaza El Mexicanobus Los Angeles
- Take the bus from Tijuana to Mexicalibus
7h 3m$603–1,584Train, bus
- Take the train from Santa Ana to San Diego Old Town Transportation Centertrain Pacific Surfliner
- Take the bus from Tijuana to Mexicalibus
6h 14m$807–1,773Drive 321.9 km
- Drive from Santa Ana to Mexicalicar 321.9 km
3h 45m$646–932Train to Los Angeles International Airport, fly to Imperial County Airport
- Take the train from Santa Ana to Los Angelestrain
- Fly from Los Angeles International Airport (LAX) to Imperial County Airport (IPL)plane LAX - IPL
4h 46m$1,758–11,682Fly John Wayne Airport Orange County to Yuma International Airport, bus
- Fly from John Wayne Airport Orange County (SNA) to Yuma International Airport (YUM)plane SNA - YUM
- Take the bus from San Luis Río Colorado to Mexicalibus
7h 20m$1,615–7,605
Santa Ana to Mexicali by bus and foot
Questions & Answers
The cheapest way to get from Santa Ana to Mexicali is to drive which costs $600 - $950 and takes 3h 45m.
The fastest way to get from Santa Ana to Mexicali is to drive which takes 3h 45m and costs $600 - $950.
No, there is no direct bus from Santa Ana to Mexicali. However, there are services departing from Santa Ana and arriving at Mexicali via Tijuana. The journey, including transfers, takes approximately 5h 7m.
The distance between Santa Ana and Mexicali is 353 km. The road distance is 321.9 km.
The best way to get from Santa Ana to Mexicali without a car is to bus via Tijuana which takes 5h 7m and costs $650 - $1200.
It takes approximately 5h 7m to get from Santa Ana to Mexicali, including transfers.
Santa Ana to Mexicali bus services, operated by Greyhound Mexico, depart from Santa Ana station.
Santa Ana to Mexicali bus services, operated by Greyhound Mexico, arrive at Tijuana - Plaza El Mexicano station.
Yes, the driving distance between Santa Ana to Mexicali is 322 km. It takes approximately 3h 45m to drive from Santa Ana to Mexicali.
Book your Santa Ana to Mexicali bus tickets online with Omio.
What companies run services between Santa Ana, CA, USA and Mexicali, Mexico?
You can take a bus from Santa Ana to Mexicali via San Ysidro and Tijuana in around 5h 7m.
- Website
- aa.com
Flights from John Wayne Airport Orange County to Yuma International Airport via Phoenix
- Ave. Duration
- 3h 36m
- When
- Every day
- Estimated price
- $1,000–6,000
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Santa Ana to San Diego Old Town Transportation Center
- Ave. Duration
- 1h 51m
- Frequency
- Hourly
- Estimated price
- $410–950
- Website
- Amtrak
Train from Santa Ana to Los Angeles
- Ave. Duration
- 53 min
- Frequency
- Hourly
- Estimated price
- $160–360
- Website
- Amtrak
- Phone
- +1 866 691 9732
- [email protected]
- Website
- Limousine Express
Bus from Santa Ana to San Ysidro
- Ave. Duration
- 1h 50m
- Frequency
- 5 times a day
- Estimated price
- $550–800
- Website
- Limousine Express
- One Way
- $550–800
Want to know more about travelling around Mexico
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More Questions & Answers
There are 98+ hotels available in Mexicali.










