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How to get fromSanta Ana to Missouriby plane, train (Amtrak), bus, car, or train

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There are 10 ways to get from Santa Ana to Missouri by plane, train (Amtrak), bus, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly John Wayne Airport Orange County to Lambert–St. Louis International Airport

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Lambert–St. Louis International Airport (STL)plane plane SNA - STL
    5h 55m
    $241–936

  2. Train to San Diego International Airport, fly to Lambert–St. Louis International Airport

    cheapest
    1. Take the train from Santa Ana to San Diego Old Town Transportation Centertrain train
    2. Fly from San Diego International Airport (SAN) to Lambert–St. Louis International Airport (STL)plane plane SAN - STL
    7h 39m
    $162–291

  3. Train (Amtrak)

    1. Take the train from Fullerton Amtrak Station to Kansas Citytrain train Southwest Chief
    35h 59m
    $557–1,209

  4. Bus

    1. Take the bus from Santa Ana to Huntington Parkbus bus 2
    2. Take the bus from 2474 E Florence Ave - Huntington Park to El Pasobus bus
    3. Take the bus from El Paso to 2745 Southwest Blvd - Kansas Citybus bus
    37h 18m
    $278–384

  5. Drive 1,552.3 mi

    1. Drive from Santa Ana to Kansas Citycar car 1,552.3 mi
    26h 41m
    $284–410

  6. Fly John Wayne Airport Orange County to Kansas City

    1. Fly from John Wayne Airport Orange County (SNA) to Kansas City (MCI)plane plane SNA - MCI
    6h 32m
    $228–933

  7. Train to Los Angeles International Airport, fly to Lambert–St. Louis International Airport

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Fly from Los Angeles International Airport (LAX) to Lambert–St. Louis International Airport (STL)plane plane LAX - STL
    7h 4m
    $211–399

  8. Train to Los Angeles International Airport, fly to Kansas City

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Fly from Los Angeles International Airport (LAX) to Kansas City (MCI)plane plane LAX - MCI
    7h 37m
    $228–456

  9. Train to San Diego International Airport, fly to Kansas City

    1. Take the train from Santa Ana to San Diego Old Town Transportation Centertrain train
    2. Fly from San Diego International Airport (SAN) to Kansas City (MCI)plane plane SAN - MCI
    8h 1m
    $219–908

  10. Train, bus

    1. Take the train from Santa Ana to L.A. Union Stationtrain train
    2. Take the bus from Los Angeles Union Station to Tulsa Bus Stationbus bus
    3. Take the bus from Tulsa to Kansas Citybus bus
    40h 29m
    $298–541

Santa Ana to Missouri by train and tram (Amtrak)

Calendar7Weekly Services
Duration35h 59mAverage Duration
Ticket$557Cheapest Price
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Questions & Answers

Map of how to get from Santa Ana to Missouri.ExpandLaunch map view
  • Distance: 1,585.2 mi
  • Duration: 5h 55m

What companies run services between Santa Ana, CA, USA and Missouri, USA?

Southwest Airlines, United Airlines, and two other airlines fly from John Wayne Airport Orange County (SNA) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, Amtrak operates a train from Fullerton Amtrak Station to Kansas City once daily. Tickets cost $550–1,200 and the journey takes 34h 31m.

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