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How to get fromSanta Ana to Otay Mesaby bus (Flixbus, Greyhound), train, tram, car, or bus (Greyhound)

Find Transport to Otay Mesa

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There are 4 ways to get from Santa Ana to Otay Mesa by bus (Flixbus, Greyhound), train, tram, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Santa Ana to San Ysidrobus bus Lxus 3105 / ...
    2h 42m
    $21–42

  2. Drive 105 mi

    cheapest
    1. Drive from Santa Ana to Otay Mesacar car 105 mi
    1h 52m
    $20–28

  3. Train, tram

    1. Take the train from Santa Ana to San Diego Old Town Transportation Centertrain train Pacific Surfliner
    2. Take the tram from Old Town Station to Iris Avenue Stationtram tram Blue
    3h 14m
    $33–76

  4. Bus, line 929 bus

    1. Take the bus from Santa Ana to San Diegobus bus Los Angeles
    2. Take the bus from 12th & Imperial Transit Center to Iris Avenue Transit Centerbus bus 929 / ...
    3h 26m
    $23–38

Santa Ana to Otay Mesa by bus

Calendar91Weekly Buses
Duration2h 42mAverage Duration
Ticket$21Cheapest Price
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Questions & Answers

Map of how to get from Santa Ana to Otay Mesa.ExpandLaunch map view
  • Distance: 117.7 mi
  • Duration: 2h 42m

What companies run services between Santa Ana, CA, USA and Otay Mesa, CA, USA?

Limousine Express operates a bus from Santa Ana to San Ysidro 5 times a day, and the journey takes 1h 50m. Four other operators also service this route.

Train operators
Bus operators

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