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How to get fromSanta Ana to San Franciscoby plane, bus (Greyhound), train (Amtrak), car, train, or bus

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There are 7 ways to get from Santa Ana to San Francisco by plane, bus (Greyhound), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to San Francisco International Airport

    best
    1. Fly from John Wayne Airport Orange County (SNA) to San Francisco International Airport (SFO)plane plane SNA - SFO
    2h 6m
    $217–745

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Santa Ana Bus Stop to San Francisco Bus Stationbus bus Greyhound US0831
    9h 45m
    $65–130

  3. Train, Caltrain

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Take the train from Los Angeles to San Josetrain train
    3. Take the train from San Jose Diridon Caltrain Northbound to San Francisco Caltrain Northboundtrain train
    13h 21m
    $150–315

  4. Drive 413.4 mi

    1. Drive from Santa Ana to San Franciscocar car 413.4 mi
    6h 53m
    $76–109

  5. Fly to Oakland International Airport

    1. Fly from John Wayne Airport Orange County (SNA) to Oakland International Airport (OAK)plane plane SNA - OAK
    2h 10m
    $273–791

  6. Fly to Norman Y. Mineta San José International Airport, Caltrain

    1. Fly from John Wayne Airport Orange County (SNA) to Norman Y. Mineta San José International Airport (SJC)plane plane SNA - SJC
    2. Take the train from Santa Clara Caltrain Northbound to San Francisco Caltrain Northboundtrain train
    3h 17m
    $230–848

  7. Train, bus

    1. Take the train from Santa Ana to L.A. Union Stationtrain train OC Line
    2. Take the bus from Los Angeles Union Station to San Franciscobus bus FlixBus 2005
    10h 49m
    $78–131

Santa Ana to San Francisco by bus (Greyhound)

Calendar7Weekly Buses
Duration9h 45mAverage Duration
Ticket$65Cheapest Price
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Questions & Answers

Map of how to get from Santa Ana to San Francisco.ExpandLaunch map view
  • Distance: 391.5 mi
  • Duration: 2h 6m

What companies run services between Santa Ana, CA, USA and San Francisco, CA, USA?

Frontier Airlines, Alaska Airlines, Inc., and two other airlines fly from John Wayne Airport Orange County (SNA) to San Francisco International Airport (SFO) hourly. Alternatively, Greyhound USA operates a bus from Santa Ana Bus Stop to San Francisco Bus Station once daily. Tickets cost $65–130 and the journey takes 9h 45m.

Airlines
Train operators
Bus operators

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Need to know: Greyhound

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