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How to get fromSanta Ana to San Luis Río Coloradoby bus (Flixbus, Greyhound), train, bus, car, plane, or bus (Greyhound)

Find Transport to San Luis Río Colorado

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There are 7 ways to get from Santa Ana to San Luis Río Colorado by bus (Flixbus, Greyhound), train, bus, car, plane, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Mexicali

    best
    1. Take the bus from Santa Ana to San Ysidrobus bus
    2. Take the bus from Tijuana to Mexicalibus bus
    3. Take the bus from Mexicali to San Luis Río Coloradobus bus
    6h 37m
    $770–2,124

  2. Train, bus

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Take the train from Los Angeles to Yuma Amtraktrain train
    3. Take the bus from 3rd Street @ Gila Street to William Brook Ave @ B Streetbus bus 95
    8h 18m
    $2,871–4,482

  3. Drive  392.3 km

    1. Drive from Santa Ana to San Luis Río Coloradocar car 392.3 km
    4h 45m
    $820–1,185

  4. Fly John Wayne Airport Orange County to Yuma International Airport

    1. Fly from John Wayne Airport Orange County (SNA) to Yuma International Airport (YUM)plane plane SNA - YUM
    5h 40m
    $1,543–6,679

  5. Train, bus via Tijuana

    1. Take the train from Santa Ana to San Diegotrain train Pacific Surfliner
    2. Take the bus from Tijuana to San Luis Río Coloradobus bus
    8h 34m
    $1,693–3,359

  6. Bus

    1. Take the bus from Santa Ana to Tijuana - Plaza El Mexicanobus bus Los Angeles
    2. Take the bus from Tijuana Buenavista to San Luis Río Coloradobus bus Ensenada
    9h 10m
    $1,123–1,684

  7. Train to Los Angeles International Airport, fly to Imperial County Airport, bus

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Fly from Los Angeles International Airport (LAX) to Imperial County Airport (IPL)plane plane LAX - IPL
    3. Take the bus from Mexicali to San Luis Río Coloradobus bus
    6h 13m
    $2,148–12,827

Santa Ana to San Luis Río Colorado by train and bus

Calendar6Weekly Services
Duration8h 18mAverage Duration
Ticket$2,871Cheapest Price
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Comparing Your Travel Options

Map of how to get from Santa Ana to San Luis Río Colorado.ExpandLaunch map view
  • Distance: 422.7 km
  • Duration: 6h 37m

What companies run services between Santa Ana, CA, USA and San Luis Río Colorado, Mexico?

You can take a bus from Santa Ana to San Luis Río Colorado via San Ysidro, Tijuana, and Mexicali in around 6h 37m. Alternatively, American Airlines and Southwest Airlines fly from John Wayne Airport Orange County (SNA) to Yuma International Airport (YUM) 5 times a day.

Airlines
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Bus operators

Want to know more about travelling around Mexico

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

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Need to know: Greyhound

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