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How to get fromSanta Ana to San Ysidroby bus (Flixbus, Greyhound), train, tram, car, or bus (Greyhound, Flixbus)

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There are 4 ways to get from Santa Ana to San Ysidro by bus (Flixbus, Greyhound), train, tram, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via San Ysidro Transit Center

    best
    1. Take the bus from Santa Ana to San Ysidrobus bus Lxus 3105 / ...
    2h 3m
    $19–38

  2. Train, tram

    1. Take the train from Santa Ana to San Diego Old Town Transportation Centertrain train Pacific Surfliner
    2. Take the tram from Old Town Station to Beyer Blvd Stationtram tram Blue
    2h 53m
    $31–71

  3. Drive 102.1 mi

    1. Drive from Santa Ana to San Ysidrocar car 102.1 mi
    1h 47m
    $19–27

  4. Bus

    1. Take the bus from Santa Ana to San Ysidrobus bus Los Angeles
    2h 30m
    $30–50

Santa Ana to San Ysidro by bus

Calendar66Weekly Buses
Duration2h 3mAverage Duration
Ticket$19Cheapest Price
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Questions & Answers

Map of how to get from Santa Ana to San Ysidro.ExpandLaunch map view
  • Distance: 110.6 mi
  • Duration: 2h 3m

What companies run services between Santa Ana, CA, USA and San Ysidro, CA, USA?

Jefferson Lines operates a bus from Santa Ana to San Ysidro 5 times a day. Tickets cost $35–50 and the journey takes 1h 50m. Two other operators also service this route.

Train operators
Bus operators

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