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How to get fromSanta Ana to St. Louisby plane, bus (Greyhound), train (Amtrak), car, or train

Find Transport to St. Louis

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There are 7 ways to get from Santa Ana to St. Louis by plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Wayne Airport Orange County

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Lambert–St. Louis International Airport (STL)plane plane SNA - STL
    5h 50m
    $181–736

  2. Train to Los Angeles International Airport, fly

    cheapest
    1. Take the train from Santa Ana to Los Angelestrain train
    2. Fly from Los Angeles International Airport (LAX) to Lambert–St. Louis International Airport (STL)plane plane LAX - STL
    6h 59m
    $149–275

  3. Bus (Greyhound)

    1. Take the bus from Santa Ana to Los Angeles Union Stationbus bus Tijuana
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus Greyhound US1210
    42h 10m
    $349–562

  4. Train via Kansas City (Amtrak)

    1. Take the train from Fullerton Amtrak Station to Kansas Citytrain train Southwest Chief
    2. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    42h 27m
    $1,107–1,749

  5. Drive  1,805.9 mi

    1. Drive from Santa Ana to St. Louiscar car 1,805.9 mi
    28h 46m
    $330–477

  6. Train to San Diego International Airport, fly

    1. Take the train from Santa Ana to San Diego Old Town Transportation Centertrain train
    2. Fly from San Diego International Airport (SAN) to Lambert–St. Louis International Airport (STL)plane plane SAN - STL
    7h 31m
    $182–268

  7. Train (Amtrak)

    1. Take the train from Santa Ana to Los Angelestrain train Pacific Surfliner
    2. Take the train from Los Angeles to St. Louistrain train Texas Eagle
    2d 9h
    $1,319–2,129

Santa Ana to St. Louis by bus (Greyhound)

Calendar7Weekly Buses
Duration42h 10mAverage Duration
Ticket$349Cheapest Price
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Comparing Your Travel Options

Map of how to get from Santa Ana to St. Louis.ExpandLaunch map view
  • Distance: 1,585.2 mi
  • Duration: 5h 50m

What companies run services between Santa Ana, CA, USA and St. Louis, MO, USA?

Southwest Airlines, American Airlines, and two other airlines fly from John Wayne Airport Orange County (SNA) to Lambert–St. Louis International Airport (STL) every 2 hours. Alternatively, you can take a bus from Santa Ana to St Louis Bus Station via Los Angeles Union Station in around 42h 10m.

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Need to know: Greyhound

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