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How to get fromSanta Ana to Winston-Salemby plane, bus (Greyhound), train (Amtrak), car, or bus

Find Transport to Winston-Salem

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There are 5 ways to get from Santa Ana to Winston-Salem by plane, bus (Greyhound), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Piedmont Triad International Airport

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Piedmont Triad International Airport (GSO)plane plane SNA - GSO
    7h 58m
    $347–1,256

  2. Fly to Charlotte Douglas International Airport, bus

    cheapest
    1. Fly from John Wayne Airport Orange County (SNA) to Charlotte Douglas International Airport (CLT)plane plane SNA - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    8h 15m
    $299–1,179

  3. Bus

    1. Take the bus from Santa Ana to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to Dallas Bus Stationbus bus
    3. Take the bus from Dallas Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus
    2d 9h
    $435–803

  4. Train (Amtrak)

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Take the train from Los Angeles to New Orleans Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to High Pointtrain train
    2d 22h
    $884–1,926

  5. Drive 2,401.6 mi

    1. Drive from Santa Ana to Winston-Salemcar car 2,401.6 mi
    39h 8m
    $439–634

Santa Ana to Winston-Salem by bus

Calendar14Weekly Buses
Duration2d 9hAverage Duration
Ticket$435Cheapest Price
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Questions & Answers

Map of how to get from Santa Ana to Winston-Salem.ExpandLaunch map view
  • Distance: 2,170.8 mi
  • Duration: 7h 58m

What companies run services between Santa Ana, CA, USA and Winston-Salem, NC, USA?

American Airlines, Delta, and United Airlines fly from John Wayne Airport Orange County (SNA) to Piedmont Triad International Airport (GSO) every 3 hours. Alternatively, you can take a bus from Santa Ana to Winston Salem(Trans Center) via Los Angeles Union Station, Dallas Bus Station, and Atlanta Bus Station in around 2d 9h.

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