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How to get fromSanta Ana to Winston-Salemby plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

Find Transport to Winston-Salem

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There are 5 ways to get from Santa Ana to Winston-Salem by plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Piedmont Triad International Airport

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Piedmont Triad International Airport (GSO)plane plane SNA - GSO
    8h 7m
    $327–1,256

  2. Fly to Charlotte Douglas International Airport, bus

    cheapest
    1. Fly from John Wayne Airport Orange County (SNA) to Charlotte Douglas International Airport (CLT)plane plane SNA - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    7h 52m
    $239–979

  3. Bus

    1. Take the bus from Santa Ana to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus
    2d 14h
    $430–702

  4. Train (Amtrak)

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Take the train from Los Angeles to New Orleans Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to High Pointtrain train
    2d 22h
    $712–1,713

  5. Drive  2,405.6 mi

    1. Drive from Santa Ana to Winston-Salemcar car 2,405.6 mi
    38h 59m
    $439–635

Santa Ana to Winston-Salem by bus

Calendar7Weekly Buses
Duration2d 14hAverage Duration
Ticket$430Cheapest Price
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Comparing Your Travel Options

Map of how to get from Santa Ana to Winston-Salem.ExpandLaunch map view
  • Distance: 2,170.8 mi
  • Duration: 8h 7m

What companies run services between Santa Ana, CA, USA and Winston-Salem, NC, USA?

Delta, American Airlines, and United Airlines fly from John Wayne Airport Orange County (SNA) to Piedmont Triad International Airport (GSO) every 2 hours. Alternatively, you can take a bus from Santa Ana to Winston Salem(Trans Center) via Los Angeles Union Station, St Louis Bus Station, and Atlanta Bus Station in around 2d 14h.

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