Rome2Rio

How to get fromSanta Clara to Cayo Guillermoby car or bus

Find Transport to Cayo Guillermo

See all options
QR code to download the Rome2Rio app

Download the Rome2Rio travel app

Scan QR code with your phone to download the app

Download on the App StoreGet it on Google Play

There are 3 ways to get from Santa Clara to Cayo Guillermo by car or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive  255 km

    best
    1. Drive from Santa Clara to Cayo Guillermocar car 255 km
    4h 8m
    $30–44

  2. Bus, drive

    1. Take the bus from Santa Clara to Cayo Santa Maríabus bus Santa Clara
    2. Drive from Cayo Santa María to Cayo Guillermocar car
    5h 54m
    $37–61

  3. Bus, drive via Valentin Perla Blanca

    1. Take the bus from Santa Clara to Cayo Santa Maríabus bus Santa Clara
    2. Drive from Valentin Perla Blanca to Cayo Guillermocar car
    6h 48m
    $38–61

Comparing Your Travel Options

Map of how to get from Santa Clara to Cayo Guillermo.ExpandLaunch map view
  • Distance: 255 km
  • Duration: 4h 8m

What companies run services between Santa Clara, Cuba and Cayo Guillermo, Cuba?

You can drive from Santa Clara to Cayo Guillermo in around 4h 8m.

Operators

Want to know more about travelling around the world?

Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including Slovenia: Getting from Ljubljana to Lake Bled, 4 stunningly beautiful Philippines islands you need to visit, and Getting to Rome from the airport - to help you get the most out of your next trip.