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How to get fromSanta Cruz to Medellínby plane, bus, or car

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There are 6 ways to get from Santa Cruz to Medellín by plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Medellin Jose Marie Cordova

    best
    1. Fly from Viru Viru International Airport (VVI) to Medellin Jose Marie Cordova (MDE)plane plane VVI - MDE
    9h 28m
    $416–861

  2. Bus via Quito

    cheapest
    1. Take the bus from Santa Cruz to La Pazbus bus
    2. Take the bus from La Paz to Lima - Terminal Arriolabus bus
    3. Take the bus from Lima Javier Prado to Terminal Terrestre Quitumbebus bus
    4. Take the bus from Terminal Terrestre Quitumbe to Tulcánbus bus
    5. Take the bus from Ipiales to Terminal de Transporte Calibus bus
    6. Take the bus from Terminal de Transporte Cali to Terminal del Surbus bus
    4d 16h
    $214–824

  3. Bus

    1. Take the bus from Santa Cruz to La Pazbus bus
    2. Take the bus from La Paz to Gran Terminal Terrestre Plaza Nortebus bus
    3. Take the bus from Gran Terminal Terrestre Plaza Norte to Rumichacabus bus
    4. Take the bus from Ipiales to Terminal de Transporte Calibus bus
    5. Take the bus from Terminal de Transporte Cali to Terminal del Surbus bus
    4d 2h
    $232–383

  4. Drive 5,149.3 km

    1. Drive from Santa Cruz de la Sierra to Medellíncar car 5,149.3 km
    3d 4h
    $269–389

  5. Fly to Enrique Olaya Herrera Airport

    1. Fly from Viru Viru International Airport (VVI) to Enrique Olaya Herrera Airport (EOH)plane plane VVI - EOH
    9h 12m
    $601–2,301

  6. Fly to Manizales, bus

    1. Fly from Viru Viru International Airport (VVI) to Manizales (MZL)plane plane VVI - MZL
    2. Take the bus from Terminal de Transportes de Manizales to Terminal del Nortebus bus
    14h 31m
    $440–1,629

Viru Viru International Airport (VVI) to Medellin Jose Marie Cordova (MDE) flights

Calendar22Weekly Planes
Duration8h 49mAverage Duration
Ticket$186Cheapest Price
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Questions & Answers

Map of how to get from Santa Cruz to Medellín.ExpandLaunch map view
  • Distance: 3,013.7 km
  • Duration: 9h 28m

What companies run services between Santa Cruz, Bolivia and Medellín, Colombia?

Avianca - Aerovías del Continente Americano S.A., Copa Airlines, and LATAM Chile fly from Viru Viru International Airport (VVI) to Medellin Jose Marie Cordova (MDE) 3 times a day. Alternatively, you can take a vehicle from Santa Cruz de la Sierra to Terminal del Sur via Santa Cruz, La Paz, Gran Terminal Terrestre Plaza Norte, Rumichaca, Terminal Ipiales, Ipiales, and Terminal de Transporte Cali in around 4d 2h.

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