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How to get fromSanta Cruz to Knoxvilleby taxi, plane, bus (Amtrak, Greyhound, Flixbus), bus, train, or car

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There are 9 ways to get from Santa Cruz to Knoxville by taxi, plane, bus (Amtrak, Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Monterey Regional Airport, fly to Mcghee Tyson Airport

    best
    1. Take the taxi from Santa Cruz to Monterey Regional Airport (MRY)taxi taxi
    2. Fly from Monterey Regional Airport (MRY) to Mcghee Tyson Airport (TYS)plane plane MRY - TYS
    8h 5m
    $499–1,540

  2. Bus to Norman Y. Mineta San José International Airport, fly to Nashville, drive

    cheapest
    1. Take the bus from Front to Diridon Stationbus bus
    2. Fly from Norman Y. Mineta San José International Airport (SJC) to Nashville (BNA)plane plane SJC - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    9h 37m
    $206–773

  3. Bus

    1. Take the bus from Front to Diridon Stationbus bus
    2. Take the bus from San Jose Diridon Station to Los Angeles Union Stationbus bus
    3. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    5. Take the bus from New York to Knoxvillebus bus
    3d 17h
    $673–1,217

  4. Bus, train

    1. Take the bus from Front to Diridon Stationbus bus
    2. Take the train from San Jose to Emeryvilletrain train
    3. Take the train from Emeryville to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus
    3d 19h
    $1,153–2,462

  5. Drive 2,422.2 mi

    1. Drive from Santa Cruz to Knoxvillecar car 2,422.2 mi
    38h 54m
    $443–639

  6. Bus to Norman Y. Mineta San José International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Front to Diridon Stationbus bus
    2. Fly from Norman Y. Mineta San José International Airport (SJC) to Mcghee Tyson Airport (TYS)plane plane SJC - TYS
    9h 24m
    $371–1,393

  7. Bus, Caltrain to San Francisco International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Front to Diridon Stationbus bus
    2. Take the train from San Jose Diridon Caltrain Northbound to Millbrae Caltrain Northboundtrain train
    3. Fly from San Francisco International Airport (SFO) to Mcghee Tyson Airport (TYS)plane plane SFO - TYS
    9h 58m
    $340–1,205

  8. Bus, train to Oakland International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Front to Diridon Stationbus bus
    2. Take the train from San Jose to Oakland Coliseum/Airport Amtraktrain train
    3. Fly from Oakland International Airport (OAK) to Mcghee Tyson Airport (TYS)plane plane OAK - TYS
    10h 35m
    $389–1,413

  9. Bus, train via Farragut

    1. Take the bus from Ocean & Water to Diridon Stationbus bus
    2. Take the bus from San Jose to Emeryvillebus bus
    3. Take the train from Emeryville to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    5. Take the bus from New York to Knoxvillebus bus
    3d 19h
    $1,194–2,537

Monterey Regional Airport (MRY) to Mcghee Tyson Airport (TYS) flights

Calendar33Weekly Planes
Duration8h 41mAverage Duration
Ticket$305Cheapest Price
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Questions & Answers

Map of how to get from Santa Cruz to Knoxville.ExpandLaunch map view
  • Distance: 2,153 mi
  • Duration: 8h 5m

What companies run services between Santa Cruz, CA, USA and Knoxville, TN, USA?

You can take a bus from Front to Knoxville via Diridon Station, San Jose Diridon Station, Los Angeles Union Station, St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 3d 17h.

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