Rome2Rio

How to get fromSanta Cruz to St. Louisby taxi, plane, bus (Amtrak, Greyhound, Flixbus), bus, train, car, or train (Amtrak)

Find Transport to St. Louis

See all options

There are 8 ways to get from Santa Cruz to St. Louis by taxi, plane, bus (Amtrak, Greyhound, Flixbus), bus, train, car, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Monterey Regional Airport, fly

    best
    1. Take the taxi from Santa Cruz to Monterey Regional Airport (MRY)taxi taxi
    2. Fly from Monterey Regional Airport (MRY) to Lambert–St. Louis International Airport (STL)plane plane MRY - STL
    7h 12m
    $337–1,023

  2. Bus, Caltrain to San Francisco International Airport, fly

    cheapest
    1. Take the bus from Front to Diridon Stationbus bus
    2. Take the train from San Jose Diridon Caltrain Northbound to Millbrae Caltrain Northboundtrain train
    3. Fly from San Francisco International Airport (SFO) to Lambert–St. Louis International Airport (STL)plane plane SFO - STL
    7h 44m
    $158–468

  3. Bus

    1. Take the bus from Front to Diridon Stationbus bus 17
    2. Take the bus from San Jose Diridon Station to Los Angeles Union Stationbus bus
    3. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    2d 2h
    $340–664

  4. Bus, train

    1. Take the bus from Front to Diridon Stationbus bus 17
    2. Take the train from San Jose to Emeryvilletrain train
    3. Take the train from Emeryville to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    5. Take the train from Springfield to St. Louistrain train
    2d 11h
    $790–1,669

  5. Drive 2,064.2 mi

    1. Drive from Santa Cruz to St. Louiscar car 2,064.2 mi
    33h 24m
    $377–545

  6. Bus to Norman Y. Mineta San José International Airport, fly

    1. Take the bus from Front to Diridon Stationbus bus
    2. Fly from Norman Y. Mineta San José International Airport (SJC) to Lambert–St. Louis International Airport (STL)plane plane SJC - STL
    8h 46m
    $209–826

  7. Bus, train to Oakland International Airport, fly

    1. Take the bus from Front to Diridon Stationbus bus
    2. Take the train from San Jose to Oakland Coliseum/Airport Amtraktrain train
    3. Fly from Oakland International Airport (OAK) to Lambert–St. Louis International Airport (STL)plane plane OAK - STL
    10h 7m
    $227–896

  8. Train (Amtrak)

    1. Take the train from Salinas to Los Angelestrain train Coast Starlight
    2. Take the train from Los Angeles to St. Louistrain train Texas Eagle
    2d 21h
    $864–1,851

Santa Cruz to St. Louis by bus

Calendar14Weekly Buses
Duration2d 2hAverage Duration
Ticket$340Cheapest Price
See schedules

Questions & Answers

Map of how to get from Santa Cruz to St. Louis.ExpandLaunch map view
  • Distance: 1,776.2 mi
  • Duration: 7h 12m

What companies run services between Santa Cruz, CA, USA and St. Louis, MO, USA?

You can take a bus from Front to St Louis Bus Station via Diridon Station, San Jose Diridon Station, and Los Angeles Union Station in around 2d 2h. Alternatively, you can take a bus from Front & Soquel Ave to St. Louis via Watsonville Transit Center / Lane 2, Salinas Transit Center / Gate 1, Salinas, and Los Angeles in around 2d 21h.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers