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How to get fromSanta Cruz to La Serenaby bus, plane, car, bus (Flixbus), or train

Find Transport to La Serena

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There are 6 ways to get from Santa Cruz to La Serena by bus, plane, car, bus (Flixbus), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly

    best
    1. Take the bus from Hospital to Terminal Sur de Santiagobus bus
    2. Fly from Comodoro Arturo Merino Benítez International Airport (SCL) to La Florida Airport (LSC)plane plane SCL - LSC
    5h 39m
    $54–121

  2. Bus

    cheapest
    1. Take the bus from Terminal de Buses Santa Cruz to Terminal Sur de Santiagobus bus Santiago
    2. Take the bus from Terminal San Borja to Terminal de buses La Serenabus bus Santiago / ...
    9h 38m
    $12–87

  3. Drive 621.1 km

    1. Drive from Santa Cruz to La Serenacar car 621.1 km
    7h 25m
    $77–111

  4. Bus via Hospital

    1. Take the bus from Hospital to Terminal Sur de Santiagobus bus Santiago
    2. Take the bus from Santiago to Terminal de buses La Serenabus bus FlixBus CL040 / ...
    9h 53m
    $55–98

  5. Bus, train

    1. Take the bus from Terminal de Buses Santa Cruz to Terminal Rodoviario de San Fernandobus bus
    2. Take the train from San Fernando to Estacion Central Alamedatrain train
    3. Take the bus from Santiago to Terminal de buses La Serenabus bus
    10h 50m
    $52–98

  6. Bus via Peralillo

    1. Take the bus from Peralillo to Terminal Sur de Santiagobus bus Santiago / ...
    2. Take the bus from Terminal Alameda - Turbus to Terminal de buses La Serenabus bus Santiago / ...
    11h 52m
    $20–118

Comodoro Arturo Merino Benítez International Airport (SCL) to La Florida Airport (LSC) flights

Calendar49Weekly Planes
Duration1h 9mAverage Duration
Ticket$17Cheapest Price
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Questions & Answers

Map of how to get from Santa Cruz to La Serena.ExpandLaunch map view
  • Distance: 622.5 km
  • Duration: 5h 39m

What companies run services between Santa Cruz, O'Higgins, Chile and La Serena, Chile?

You can take a bus from Terminal de Buses Santa Cruz to Terminal de buses La Serena via Terminal Sur de Santiago and Terminal San Borja in around 9h 38m.

Airlines
Train operators
Bus operators

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