There are 4 ways to get from Santa Cruz de la Sierra to Guayaquil by plane, bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Viru Viru International Airport (VVI) to José Joaquín De Olmedo International Airport (GYE)plane VVI - GYE
10h 13m$401–701Bus via Tumbes
cheapest- Take the bus from Santa Cruz to La Pazbus
- Take the bus from La Paz to Oltursa Lima Terminalbus
- Take the bus from Lima - Surquillo to Tumbesbus
- Take the bus from Tumbes to Terminal Terrestre de Guayaquilbus
3d 5h$153–220Bus
- Take the bus from Santa Cruz to La Pazbus
- Take the bus from La Paz to Gran Terminal Terrestre Plaza Nortebus
- Take the bus from Gran Terminal Terrestre Plaza Norte to Terminal Terrestre de Guayaquilbus
3d 3h$156–240Drive 3,722.8 km
- Drive from Santa Cruz de la Sierra to Guayaquilcar 3,722.8 km
2d 4h$212–305
Viru Viru International Airport (VVI) to José Joaquín De Olmedo International Airport (GYE) flights
Questions & Answers
The cheapest way to get from Santa Cruz de la Sierra to Guayaquil is to bus via Tumbes which costs $150 - $220 and takes 3 days 5h.
The fastest way to get from Santa Cruz de la Sierra to Guayaquil is to fly which takes 10h 13m and costs $400 - $700.
No, there is no direct bus from Santa Cruz de la Sierra to Guayaquil. However, there are services departing from Santa Cruz and arriving at Terminal Terrestre de Guayaquil via La Paz and Gran Terminal Terrestre Plaza Norte. The journey, including transfers, takes approximately 3 days 3h.
The distance between Santa Cruz de la Sierra and Guayaquil is 2531 km. The road distance is 3722.8 km.
The best way to get from Santa Cruz de la Sierra to Guayaquil without a car is to bus which takes 3 days 3h and costs $150 - $240.
It takes approximately 10h 13m to get from Santa Cruz de la Sierra to Guayaquil, including transfers.
Santa Cruz de la Sierra to Guayaquil bus services, operated by Trans Copacabana SA, depart from Santa Cruz station.
The best way to get from Santa Cruz de la Sierra to Guayaquil is to fly which takes 10h 13m and costs $400 - $700. Alternatively, you can bus, which costs $150 - $240 and takes 3 days 3h.
Santa Cruz de la Sierra to Guayaquil bus services, operated by Trans Copacabana SA, arrive at La Paz station.
Guayaquil is 1h behind Santa Cruz de la Sierra. It is currently 11:59 AM in Santa Cruz de la Sierra and 10:59 AM in Guayaquil.
What companies run services between Santa Cruz de la Sierra, Bolivia and Guayaquil, Ecuador?
Copa Airlines, LATAM Chile, and two other airlines fly from Viru Viru International Airport (VVI) to José Joaquín De Olmedo International Airport (GYE) 4 times a day. Alternatively, you can take a bus from Santa Cruz to Terminal Terrestre de Guayaquil via La Paz and Gran Terminal Terrestre Plaza Norte in around 3d 3h.
- Website
- copaair.com
Flights from Viru Viru International Airport to José Joaquín De Olmedo International Airport via Panama City
- Ave. Duration
- 10h 14m
- When
- Monday, Tuesday, Thursday, and Saturday
- Estimated price
- $210–850
- Website
- latam.com
Flights from Viru Viru International Airport to José Joaquín De Olmedo International Airport via Lima
- Ave. Duration
- 9h 2m
- When
- Every day
- Estimated price
- $220–750
- Website
- avianca.com
Flights from Viru Viru International Airport to José Joaquín De Olmedo International Airport via Bogota
- Ave. Duration
- 12h
- When
- Every day
- Estimated price
- $310–1,100
- Phone
- +591-72233555
- [email protected]
- Website
- Trans Copacabana SA
Bus from Santa Cruz to La Paz
- Ave. Duration
- 18h
- Frequency
- 4 times a day
- Estimated price
- $19–25
- Schedules at
- Trans Copacabana SA
Bus from Santa Cruz to La Paz
- Ave. Duration
- 18h
- Frequency
- 4 times a day
- Estimated price
- $19–25
- Schedules at
- Trans Copacabana SA
- Phone
- +591 71861725
- Website
- Expreso del Sur
Bus from Santa Cruz to La Paz
- Ave. Duration
- 14h
- Frequency
- Once daily
- Estimated price
- $40–55
- Schedules at
- Expreso del Sur
Bus from Santa Cruz to La Paz
- Ave. Duration
- 14h
- Frequency
- Once daily
- Estimated price
- $40–55
- Schedules at
- Expreso del Sur
- Phone
- +591 69414917
- Website
- Flota Bolivar
Bus from Santa Cruz to La Paz
- Ave. Duration
- 16h 20m
- Frequency
- Once daily
- Estimated price
- $7–20
- Schedules at
- Flota Bolivar
- Normal
- $7–10
- Semicama
- $11–14
- Cama
- $17–19
Bus from Santa Cruz to La Paz
- Ave. Duration
- 16h 20m
- Frequency
- Once daily
- Estimated price
- $7–20
- Schedules at
- Flota Bolivar
- Normal
- $7–10
- Semicama
- $11–14
- Cama
- $17–19
- Phone
- +591 69416892
- [email protected]
- Website
- Cosmos
Bus from Santa Cruz to La Paz
- Ave. Duration
- 18h
- Frequency
- Once daily
- Estimated price
- $9–13
- Schedules at
- Cosmos
Bus from Santa Cruz to La Paz
- Ave. Duration
- 18h
- Frequency
- Once daily
- Estimated price
- $9–13
- Schedules at
- Cosmos
- Phone
- +59176400493
- Website
- flotaeldorado.com
Bus from Santa Cruz to La Paz
- Ave. Duration
- 18h
- Frequency
- Once daily
- Estimated price
- $19–65
- Schedules at
- flotaeldorado.com
- Book at
- flotaeldorado.com
Bus from Santa Cruz to La Paz
- Ave. Duration
- 18h
- Frequency
- Once daily
- Estimated price
- $19–65
- Schedules at
- flotaeldorado.com
- Book at
- flotaeldorado.com
- Phone
- +591 2 228 1920
- [email protected]
- Website
- facebook.com
Bus from La Paz to Gran Terminal Terrestre Plaza Norte
- Ave. Duration
- 28h 53m
- Frequency
- Once daily
- Estimated price
- $48
- Schedules at
- redbus.pe
- Phone
- +51 9 6788 4526
- [email protected]
- Website
- Lineas De Los Andes
Bus from Gran Terminal Terrestre Plaza Norte to Terminal Terrestre de Guayaquil
- Ave. Duration
- 27h
- Frequency
- Once daily
- Estimated price
- $100–130
- Website
- Lineas De Los Andes
- Phone
- +591 2245 8945
- [email protected]
- Website
- vicuna-travel.com
Bus from La Paz to Oltursa Lima Terminal
- Ave. Duration
- 30h
- Frequency
- Twice daily
- Estimated price
- $103
- Schedules at
- ticketsbolivia.com.bo
- Book at
- ticketsbolivia.com.bo
- Phone
- +51 994 656 518
- [email protected]
- Website
- Oltursa
Bus from Lima - Surquillo to Tumbes
- Ave. Duration
- 23h 15m
- Frequency
- 3 times a day
- Estimated price
- $29–40
- Website
- Oltursa
- Phone
- +51 1 311-5050
- Website
- Cruz Del Sur International
Bus from Tumbes to Terminal Terrestre de Guayaquil
- Ave. Duration
- 3h 16m
- Frequency
- Twice daily
- Estimated price
- $13–15
- Website
- Cruz Del Sur International
Want to know more about travelling around the world?
Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including 5 incredible day trips from Florence by train, Italian Lakes: Getting around by train, and The London Underground: Essential tips to navigate the Tube - to help you get the most out of your next trip.
More Questions & Answers
Yes, the driving distance between Santa Cruz de la Sierra to Guayaquil is 3723 km. It takes approximately 2 days 4h to drive from Santa Cruz de la Sierra to Guayaquil.
There are 455+ hotels available in Guayaquil.























