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How to get fromSanta Cruz de la Sierra to La Serenaby plane, bus (Flixbus), car, or bus

Find Transport to La Serena

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There are 5 ways to get from Santa Cruz de la Sierra to La Serena by plane, bus (Flixbus), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Viru Viru International Airport (VVI) to La Florida Airport (LSC)plane plane VVI - LSC
    9h 7m
    $311–451

  2. Bus via Antofagasta

    cheapest
    1. Take the bus from Santa Cruz to Terminal de Buses Cardenal Carlos Oviedo Cavadabus bus Santa Cruz
    2. Take the bus from Terminal de Buses Cardenal Carlos Oviedo Cavada to Terminal de buses La Serenabus bus Calama / ...
    33h 59m
    $59–119

  3. Bus

    1. Take the bus from Santa Cruz to Iquiquebus bus Santa Cruz
    2. Take the bus from Rodovario de Iquique to Terminal de buses La Serenabus bus Iquique / ...
    31h 42m

  4. Drive 2,198.3 km

    1. Drive from Santa Cruz de la Sierra to La Serenacar car 2,198.3 km
    30h 17m
    $271–392

  5. Bus #2

    1. Take the bus from Santa Cruz to Terminal Mendozabus bus
    2. Take the bus from Terminal Mendoza to Terminal de buses La Serenabus bus San Juan
    43h 45m
    $140–238

Viru Viru International Airport (VVI) to La Florida Airport (LSC) flights

Calendar2Weekly Planes
Duration8h 14mAverage Duration
Ticket$181Cheapest Price
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Questions & Answers

Map of how to get from Santa Cruz de la Sierra to La Serena.ExpandLaunch map view
  • Distance: 1,608.9 km
  • Duration: 9h 7m

What companies run services between Santa Cruz de la Sierra, Bolivia and La Serena, Chile?

LATAM Chile flies from Viru Viru International Airport (VVI) to La Florida Airport (LSC) twice a week. Alternatively, you can take a bus from Santa Cruz to Terminal de buses La Serena via Rodovario de Iquique in around 31h 42m.

Airlines
Bus operators

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