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How to get fromSanta Fe to Santiagoby plane, bus, car, or bus (Flixbus)

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There are 7 ways to get from Santa Fe to Santiago by plane, bus, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from General Justo José De Urquiza Airport

    best
    1. Fly from General Justo José De Urquiza Airport (PRA) to Comodoro Arturo Merino Benítez International Airport (SCL)plane plane PRA - SCL
    6h 2m
    $161–627

  2. Bus

    cheapest
    1. Take the bus from Terminal de Santa Fe Gral. Belgrano to Terminal Mendozabus bus
    2. Take the bus from Terminal Mendoza to Terminal Sur de Santiagobus bus Santiago
    23h
    $60–127

  3. Drive 1,234.6 km

    1. Drive from Santa Fe to Santiagocar car 1,234.6 km
    14h 32m
    $153–220

  4. Fly from Sauce Viejo Airport

    1. Fly from Sauce Viejo Airport (SFN) to Comodoro Arturo Merino Benítez International Airport (SCL)plane plane SFN - SCL
    8h 19m
    $171–567

  5. Bus via Los Andes

    1. Take the bus from Terminal de Santa Fe Gral. Belgrano to Terminal Mendozabus bus
    2. Take the bus from Terminal Mendoza to Los Andes - El Saucebus bus
    3. Take the bus from Espacio Urbano-Los Andes to Santiagobus bus
    24h 3m
    $74–135

  6. Bus via Los Andes #2

    1. Take the bus from Terminal de Santa Fe Gral. Belgrano to Terminal Mendozabus bus
    2. Take the bus from Terminal Mendoza to Los Andesbus bus
    3. Take the bus from Los Andes to Terminal Los Héroesbus bus
    24h 35m
    $63–175

  7. Bus via San Martín

    1. Take the bus from Terminal de Santa Fe Gral. Belgrano to Terminal Gral. San Martínbus bus
    2. Take the bus from Terminal Gral. San Martín to Terminal Mendozabus bus
    3. Take the bus from Terminal Mendoza to Terminal Alameda - Turbusbus bus
    26h 13m
    $71–168

Santa Fe to Santiago by bus

Calendar14Weekly Buses
Duration23hAverage Duration
Ticket$60Cheapest Price
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Questions & Answers

Map of how to get from Santa Fe to Santiago.ExpandLaunch map view
  • Distance: 1,029 km
  • Duration: 6h 2m

What companies run services between Santa Fe, Argentina and Santiago, Chile?

Aerolíneas Argentinas and LATAM Chile fly from General Justo José De Urquiza Airport (PRA) to Comodoro Arturo Merino Benítez International Airport (SCL) once daily. Alternatively, you can take a bus from Terminal de Santa Fe Gral. Belgrano to Terminal Sur de Santiago via Terminal Mendoza in around 23h.

Airlines
Bus operators

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