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How to get fromSanta Fe Depot to Chicago Union Stationby plane, train (Amtrak), bus (Amtrak, Greyhound, Flixbus), car, or train

Find Transport to Chicago Union Station

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There are 6 ways to get from Santa Fe Depot to Chicago Union Station by plane, train (Amtrak), bus (Amtrak, Greyhound, Flixbus), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Chicago Midway International Airport

    best
    1. Fly from San Diego International Airport (SAN) to Chicago Midway International Airport (MDW)plane plane SAN - MDW
    5h 59m
    $124–560

  2. Fly to Chicago O'Hare International Airport

    cheapest
    1. Fly from San Diego International Airport (SAN) to Chicago O'Hare International Airport (ORD)plane plane SAN - ORD
    6h 20m
    $104–460

  3. Train (Amtrak)

    1. Take the train from San Diego to Fullerton Amtrak Stationtrain train Pacific Surfliner
    2. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train Southwest Chief
    46h 6m
    $733–1,567

  4. Bus

    1. Take the bus from San Diego to Los Angelesbus bus
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus
    2d 3h
    $373–696

  5. Drive 2,074.1 mi

    1. Drive from Santa Fe Depot to Chicago Union Stationcar car 2,074.1 mi
    32h 38m
    $379–547

  6. Fly to General Mitchell International Airport, train

    1. Fly from San Diego International Airport (SAN) to General Mitchell International Airport (MKE)plane plane SAN - MKE
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    8h 24m
    $222–879

Santa Fe Depot to Chicago Union Station by train (Amtrak)

Calendar7Weekly Trains
Duration46h 6mAverage Duration
Ticket$733Cheapest Price
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Questions & Answers

Map of how to get from Santa Fe Depot to Chicago Union Station.ExpandLaunch map view
  • Distance: 1,740.9 mi
  • Duration: 5h 59m

What companies run services between Santa Fe Depot, San Diego County, CA, USA and Chicago Union Station, IL, USA?

Southwest Airlines flies from San Diego International Airport (SAN) to Chicago Midway International Airport (MDW) every 4 hours. Alternatively, you can take a train from San Diego to Chicago Union Station via Fullerton Amtrak Station in around 46h 6m.

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