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How to get fromSanta Fe Depot to San Franciscoby plane, bus (Greyhound), train (Amtrak), car, train, shuttle, bus, or subway

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There are 8 ways to get from Santa Fe Depot to San Francisco by plane, bus (Greyhound), train (Amtrak), car, train, shuttle, bus, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to San Francisco International Airport

    best
    1. Fly from San Diego International Airport (SAN) to San Francisco International Airport (SFO)plane plane SAN - SFO
    3h 17m
    $72–247

  2. Bus (Greyhound)

    1. Take the bus from San Diego Greyhound Bus Stop to Oaklandbus bus Greyhound US0831
    12h 18m
    $79–149

  3. Train, Caltrain

    1. Take the train from San Diego to Los Angelestrain train
    2. Take the train from Los Angeles to San Josetrain train
    3. Take the train from San Jose Diridon Caltrain Northbound to San Francisco Caltrain Northboundtrain train
    15h 24m
    $179–375

  4. Drive 501.3 mi

    1. Drive from Santa Fe Depot to San Franciscocar car 501.3 mi
    8h 25m
    $92–133

  5. Fly to Oakland International Airport

    1. Fly from San Diego International Airport (SAN) to Oakland International Airport (OAK)plane plane SAN - OAK
    3h 32m
    $82–273

  6. Fly to Norman Y. Mineta San José International Airport, Caltrain

    1. Fly from San Diego International Airport (SAN) to Norman Y. Mineta San José International Airport (SJC)plane plane SAN - SJC
    2. Take the train from Santa Clara Caltrain Northbound to San Francisco Caltrain Northboundtrain train
    4h 33m
    $84–520

  7. Fly to Sonoma County Airport, shuttle

    1. Fly from San Diego International Airport (SAN) to Sonoma County Airport (STS)plane plane SAN - STS
    2. Take a shuttle bus from Santa Rosa Airport to San Francisco Pier 27shuttle bus
    5h 18m
    $168–305

  8. Bus, BART

    1. Take the bus from San Ysidro to San Jose - King Rdbus bus San Ysidro
    2. Take the subway from Berryessa / North San Jose to Civic Center / UN Plazasubway subway Green-S
    14h
    $102–152

Santa Fe Depot to San Francisco by tram, bus, and subway (Greyhound)

Calendar14Weekly Services
Duration12h 18mAverage Duration
Ticket$79Cheapest Price
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Questions & Answers

Map of how to get from Santa Fe Depot to San Francisco.ExpandLaunch map view
  • Distance: 463.9 mi
  • Duration: 3h 17m

What companies run services between Santa Fe Depot, San Diego County, CA, USA and San Francisco, CA, USA?

Alaska Airlines, Inc., Frontier Airlines, and three other airlines fly from San Diego International Airport (SAN) to San Francisco International Airport (SFO) hourly. Alternatively, Greyhound USA operates a bus from San Diego Greyhound Bus Stop to Oakland twice daily. Tickets cost $75–150 and the journey takes 10h 55m.

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Need to know: Greyhound

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