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How to get fromSanta Fe Depot to Tucsonby plane, bus (Greyhound, Flixbus), bus, train, car, or train (Amtrak)

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There are 7 ways to get from Santa Fe Depot to Tucson by plane, bus (Greyhound, Flixbus), bus, train, car, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Tucson

    best
    1. Fly from San Diego International Airport (SAN) to Tucson (TUS)plane plane SAN - TUS
    3h 44m
    $442–805

  2. Drive 410 mi

    cheapest
    1. Drive from Santa Fe Depot to Tucsoncar car 410 mi
    6h 30m
    $75–109

  3. Bus via Phoenix

    1. Take the bus from San Diego Greyhound Bus Stop to Phoenix Bus Stationbus bus Greyhound US0851S
    2. Take the bus from Phoenix Sky Harbor Airport/44th Street Sky Train Station to Tucson Downtownbus bus FlixBus 2042 / ...
    12h 21m
    $79–143

  4. Bus, train

    1. Take the bus from El Cajon Transit Center to Yuma County Area Transitbus bus Greyhound US0851S
    2. Take the train from Yuma Amtrak to Tucson Amtrak Stationtrain train Texas Eagle / ...
    12h 44m
    $110–242

  5. Fly to Phoenix, bus

    1. Fly from San Diego International Airport (SAN) to Phoenix (PHX)plane plane SAN - PHX
    2. Take the bus from Sky Harbor International Airport to University of Phoenixbus bus
    5h 23m
    $162–1,040

  6. Train (Amtrak)

    1. Take the train from San Diego to Los Angelestrain train Pacific Surfliner
    2. Take the train from Los Angeles to Tucson Amtrak Stationtrain train Texas Eagle / ...
    13h 34m
    $201–413

  7. Bus

    1. Take the bus from San Diego - Santa Fe Depot to Cross Border Xpressbus bus 4.1
    2. Take the bus from Cross Border Express, San Diego to Tucsonbus bus Cbx
    25h 7m
    $97–152

Santa Fe Depot to Tucson by tram and bus

Calendar7Weekly Services
Duration12h 21mAverage Duration
Ticket$79Cheapest Price
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Questions & Answers

Map of how to get from Santa Fe Depot to Tucson.ExpandLaunch map view
  • Distance: 379.8 mi
  • Duration: 3h 44m

What companies run services between Santa Fe Depot, San Diego County, CA, USA and Tucson, AZ, USA?

Southwest Airlines, American Airlines, and Alaska Airlines, Inc. fly from San Diego International Airport (SAN) to Tucson (TUS) every 4 hours. Alternatively, you can take a vehicle from Santa Fe Depot to Broadway/Country Club via Old Town Station, San Diego Greyhound Bus Stop, Phoenix, Bus Station (E Buckeye Rd), 24th St Station, Phoenix Sky Harbor Airport/44th Street Sky Train Station, Phoenix Sky Harbor Airport/44th Street Sky Train Station, Tucson Downtown, and Downtown Ronstadt Center in around 12h 21m.

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