There are 5 ways to get from Santa Fe to Des Moines by plane, bus (Greyhound, Flixbus), train, bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Des Moines
best- Fly from Santa Fe Municipal Airport (SAF) to Des Moines (DSM)plane SAF - DSM
4h 51m$178–796Fly to Fort Dodge Municipal Airport, drive
cheapest- Fly from Santa Fe Municipal Airport (SAF) to Fort Dodge Municipal Airport (FOD)plane SAF - FOD
- Drive from Fort Dodge Municipal Airport (FOD) to Des Moinescar
11h 55m$122–470Bus
- Take the bus from Santa Fe to Pueblo, CObus
- Take the bus from Pueblo Transit to Denver Union Stationbus
- Take the bus from Denver Union Station to Des Moinesbus
21h 31m$188–327Train, bus
- Take the train from Lamy Station to Kansas Citytrain Southwest Chief
- Take the bus from Kansas City Bus Station to Des Moinesbus Greyhound US0156
23h 9m$295–619Drive 943.7 mi
- Drive from Santa Fe to Des Moinescar 943.7 mi
16h 4m$173–249
Santa Fe to Des Moines by bus, train, and foot
Questions & Answers
The cheapest way to get from Santa Fe to Des Moines is to drive which costs $170 - $250 and takes 16h 4m.
The fastest way to get from Santa Fe to Des Moines is to fly which takes 4h 51m and costs $170 - $800.
No, there is no direct bus from Santa Fe to Des Moines. However, there are services departing from Santa Fe and arriving at Des Moines via Pueblo Transit and Denver Union Station. The journey, including transfers, takes approximately 21h 31m.
The distance between Santa Fe and Des Moines is 807 miles. The road distance is 949.2 miles.
The best way to get from Santa Fe to Des Moines without a car is to bus which takes 21h 31m and costs $180 - $330.
It takes approximately 4h 51m to get from Santa Fe to Des Moines, including transfers.
Santa Fe to Des Moines bus services, operated by Omnibus Express, depart from Santa Fe station.
The best way to get from Santa Fe to Des Moines is to fly which takes 4h 51m and costs $170 - $800. Alternatively, you can bus, which costs $180 - $330 and takes 21h 31m.
Santa Fe to Des Moines bus services, operated by Omnibus Express, arrive at Pueblo, CO station.
Des Moines is 1h ahead of Santa Fe. It is currently 5:25 AM in Santa Fe and 6:25 AM in Des Moines.
What companies run services between Santa Fe, NM, USA and Des Moines, IA, USA?
United Airlines and American Airlines fly from Santa Fe Municipal Airport (SAF) to Des Moines (DSM) every 4 hours. Alternatively, you can take a vehicle from Santa Fe to Des Moines via Santa Fe, Pueblo Transit, and Denver Union Station in around 21h 31m.
- Website
- united.com
Flights from Santa Fe Municipal Airport to Des Moines via Denver
- Ave. Duration
- 4h 59m
- When
- Every day
- Estimated price
- $140–750
Flights from Santa Fe Municipal Airport to Fort Dodge Municipal Airport via Denver
- Ave. Duration
- 15h 19m
- When
- Every day
- Estimated price
- $85–420
Flights from Santa Fe Municipal Airport to Fort Dodge Municipal Airport via Chicago O'Hare
- Ave. Duration
- 10h 4m
- When
- Every day
- Estimated price
- $120–550
Flights from Santa Fe Municipal Airport to Fort Dodge Municipal Airport via Denver, Chicago O'Hare
- Ave. Duration
- 9h 42m
- When
- Every day
- Estimated price
- $130–550
- Website
- aa.com
Flights from Santa Fe Municipal Airport to Des Moines via Dallas/Ft.Worth
- Ave. Duration
- 5h 42m
- When
- Every day
- Estimated price
- $170–800
Flights from Santa Fe Municipal Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 5h 35m
- When
- Every day
- Estimated price
- $200–900
Flights from Santa Fe Municipal Airport to Des Moines via Phoenix
- Ave. Duration
- 7h 21m
- When
- Sunday
- Estimated price
- $210–950
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Lamy Station to Kansas City
- Ave. Duration
- 16h 40m
- Frequency
- Once daily
- Estimated price
- $260–550
- Website
- Amtrak
- Phone
- +1 800-923-1799
- [email protected]
- Website
- Omnibus Express
Bus from Santa Fe to Pueblo, CO
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $65–85
- Schedules at
- Omnibus Express
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Pueblo Transit to Denver Union Station
- Ave. Duration
- 2h 25m
- Frequency
- 3 times a day
- Estimated price
- $17–35
- Website
- Greyhound
Bus from Denver Union Station to Des Moines
- Ave. Duration
- 13h
- Frequency
- Twice daily
- Estimated price
- $100–200
- Website
- Greyhound
Bus from Kansas City Bus Station to Des Moines
- Ave. Duration
- 3h 10m
- Frequency
- Twice daily
- Estimated price
- $29–60
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Pueblo Transit to Denver Union Station
- Ave. Duration
- 2h 30m
- Frequency
- Twice daily
- Estimated price
- $18–30
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
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More Questions & Answers
Yes, the driving distance between Santa Fe to Des Moines is 949 miles. It takes approximately 16h 4m to drive from Santa Fe to Des Moines.
There are 241+ hotels available in Des Moines.










