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How to get fromSanta Fe to Key Westby plane, train, bus, ferry, or car

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There are 5 ways to get from Santa Fe to Key West by plane, train, bus, ferry, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Santa Fe Municipal Airport

    best
    1. Fly from Santa Fe Municipal Airport (SAF) to Key West International Airport (EYW)plane plane SAF - EYW
    6h 34m
    $142–518

  2. Train, bus, ferry

    1. Take the train from Santa Fe Depot Rail Runner Station to Downtown Albuquerque Rail Runner Stationtrain train
    2. Take the bus from ABQ Alvarado Transportation Center to El Paso Bus Stationbus bus
    3. Take the bus from El Paso Bus Station to Houston Bus Stationbus bus
    4. Take the bus from Houston - Harrisburg Blvd to Fort Myersbus bus
    5. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    2d 1h
    $506–718

  3. Train, bus

    1. Take the train from Lamy Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus
    3d 9h
    $1,106–2,327

  4. Drive 2,080 mi

    1. Drive from Santa Fe to Key Westcar car 2,080 mi
    36h 6m
    $380–549

  5. Train to Albuquerque International Airport, fly

    1. Take the train from Santa Fe Depot Rail Runner Station to Downtown Albuquerque Rail Runner Stationtrain train
    2. Fly from Albuquerque International Airport (ABQ) to Key West International Airport (EYW)plane plane ABQ - EYW
    10h 15m
    $147–622

Santa Fe to Key West by bus, train, taxi, and foot

Calendar7Weekly Services
Duration3d 9hAverage Duration
Ticket$1,106Cheapest Price
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Questions & Answers

Map of how to get from Santa Fe to Key West.ExpandLaunch map view
  • Distance: 1,649 mi
  • Duration: 6h 34m

What companies run services between Santa Fe, NM, USA and Key West, FL, USA?

American Airlines flies from Santa Fe Municipal Airport (SAF) to Key West International Airport (EYW) 3 times a day.

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