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How to get fromSanta Fe to Knoxvilleby plane, bus (Greyhound, Flixbus), train, bus, or car

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There are 9 ways to get from Santa Fe to Knoxville by plane, bus (Greyhound, Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Santa Fe Municipal Airport to Mcghee Tyson Airport

    best
    1. Fly from Santa Fe Municipal Airport (SAF) to Mcghee Tyson Airport (TYS)plane plane SAF - TYS
    6h 19m
    $296–1,195

  2. Fly Santa Fe Municipal Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Santa Fe Municipal Airport (SAF) to Asheville Regional Airport (AVL)plane plane SAF - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    7h 51m
    $163–610

  3. Bus

    1. Take the bus from Santa Fe to Denverbus bus
    2. Take the bus from Denver Union Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to New York Midtownbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    2d 11h
    $552–883

  4. Train, bus

    1. Take the train from Lamy Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    2d 13h
    $869–1,762

  5. Drive 1,385.3 mi

    1. Drive from Santa Fe to Knoxvillecar car 1,385.3 mi
    21h 47m
    $253–366

  6. Fly Santa Fe Municipal Airport to Chattanooga Metropolitan Airport, drive

    1. Fly from Santa Fe Municipal Airport (SAF) to Chattanooga Metropolitan Airport (CHA)plane plane SAF - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    7h 29m
    $249–1,053

  7. Train to Albuquerque International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Santa Fe Depot Rail Runner Station to Downtown Albuquerque Rail Runner Stationtrain train
    2. Fly from Albuquerque International Airport (ABQ) to Mcghee Tyson Airport (TYS)plane plane ABQ - TYS
    8h 35m
    $321–1,279

  8. Train, bus via Ossining

    1. Take the train from Lamy Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 13h
    $824–1,689

  9. Train, bus #2

    1. Take the train from Lamy Station to Chicago Union Stationtrain train
    2. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 17h
    $645–1,224

Santa Fe Municipal Airport (SAF) to Mcghee Tyson Airport (TYS) flights

Calendar40Weekly Planes
Duration6h 45mAverage Duration
Ticket$225Cheapest Price
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Questions & Answers

Map of how to get from Santa Fe to Knoxville.ExpandLaunch map view
  • Distance: 1,260 mi
  • Duration: 6h 19m

What companies run services between Santa Fe, NM, USA and Knoxville, TN, USA?

American Airlines and United Airlines fly from Santa Fe Municipal Airport (SAF) to Mcghee Tyson Airport (TYS) every 4 hours. Alternatively, you can take a vehicle from Santa Fe to Knoxville via Santa Fe, Denver, 18th St & California St, Union Station Gate B2, Denver Union Station, Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 2d 11h.

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