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How to get fromSanta Fe to Louisvilleby plane, bus (Greyhound), train, bus, or car

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There are 7 ways to get from Santa Fe to Louisville by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Santa Fe Municipal Airport to Louisville International Airport

    best
    1. Fly from Santa Fe Municipal Airport (SAF) to Louisville International Airport (SDF)plane plane SAF - SDF
    6h 39m
    $182–778

  2. Fly Santa Fe Municipal Airport to Evansville, bus

    cheapest
    1. Fly from Santa Fe Municipal Airport (SAF) to Evansville (EVV)plane plane SAF - EVV
    2. Take the bus from Evansville, IN to Louisville, KYbus bus
    8h 55m
    $176–595

  3. Bus

    1. Take the bus from Santa Fe to Albuquerquebus bus
    2. Take the bus from Albuquerque Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    4. Take the bus from Evansville, IN to Louisville, KYbus bus
    32h 14m
    $244–439

  4. Train, bus (Amtrak)

    1. Take the train from Lamy Station to Chicago Union Stationtrain train Southwest Chief
    2. Take the bus from Chicago Union Station to Louisville, KYbus bus Chicago
    34h 28m
    $456–919

  5. Drive 1,257.7 mi

    1. Drive from Santa Fe to Louisvillecar car 1,257.7 mi
    21h 18m
    $230–332

  6. Fly Santa Fe Municipal Airport to Blue Grass Airport, drive

    1. Fly from Santa Fe Municipal Airport (SAF) to Blue Grass Airport (LEX)plane plane SAF - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 44m
    $274–1,144

  7. Train to Albuquerque International Airport, fly to Louisville International Airport

    1. Take the train from Santa Fe Depot Rail Runner Station to Downtown Albuquerque Rail Runner Stationtrain train
    2. Fly from Albuquerque International Airport (ABQ) to Louisville International Airport (SDF)plane plane ABQ - SDF
    9h 53m
    $197–912

Santa Fe to Louisville by bus and train (Amtrak)

Calendar7Weekly Services
Duration34h 28mAverage Duration
Ticket$456Cheapest Price
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Questions & Answers

Map of how to get from Santa Fe to Louisville.ExpandLaunch map view
  • Distance: 1,151.9 mi
  • Duration: 6h 39m

What companies run services between Santa Fe, NM, USA and Louisville, KY, USA?

United Airlines and American Airlines fly from Santa Fe Municipal Airport (SAF) to Louisville International Airport (SDF) every 4 hours. Alternatively, you can take a bus from Downtown Transit Center to Louisville, KY via Santa Fe, Albuquerque, Albuquerque Bus Station, St Louis Bus Station, and Evansville, IN in around 32h 14m.

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