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How to get fromSanta Fe to Mayo Clinicby plane, train, bus, shuttle, bus (Greyhound), or car

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There are 10 ways to get from Santa Fe to Mayo Clinic by plane, train, bus, shuttle, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Santa Fe Municipal Airport to Rochester

    best
    1. Fly from Santa Fe Municipal Airport (SAF) to Rochester (RST)plane plane SAF - RST
    7h 39m
    $117–535

  2. Train, bus, shuttle

    1. Take the train from Lamy Station to Kansas Citytrain train
    2. Take the bus from Kansas City to Owatonnabus bus
    3. Take a shuttle bus from Owatonna, MN to Rochestershuttle bus
    29h 14m
    $361–729

  3. Bus

    1. Take the bus from Santa Fe to Albuquerquebus bus
    2. Take the bus from Albuquerque Bus Station to Tulsa Bus Stationbus bus
    3. Take the bus from Tulsa to St. Paulbus bus
    4. Take the bus from St. Paul to Rochesterbus bus
    34h 17m
    $307–484

  4. Drive 1,150.7 mi

    1. Drive from Santa Fe to Mayo Cliniccar car 1,150.7 mi
    19h 30m
    $210–304

  5. Fly Santa Fe Municipal Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Santa Fe Municipal Airport (SAF) to Minneapolis–Saint Paul International Airport (MSP)plane plane SAF - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 35m
    $183–627

  6. Fly Santa Fe Municipal Airport to Fort Dodge Municipal Airport, drive

    1. Fly from Santa Fe Municipal Airport (SAF) to Fort Dodge Municipal Airport (FOD)plane plane SAF - FOD
    2. Drive from Fort Dodge Municipal Airport (FOD) to Mayo Cliniccar car
    13h 21m
    $136–505

  7. Train to Albuquerque International Airport, fly to Rochester

    1. Take the train from Santa Fe Depot Rail Runner Station to Downtown Albuquerque Rail Runner Stationtrain train
    2. Fly from Albuquerque International Airport (ABQ) to Rochester (RST)plane plane ABQ - RST
    11h 40m
    $117–649

  8. Train to Albuquerque International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Santa Fe Depot Rail Runner Station to Downtown Albuquerque Rail Runner Stationtrain train
    2. Fly from Albuquerque International Airport (ABQ) to Minneapolis–Saint Paul International Airport (MSP)plane plane ABQ - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 5m
    $188–761

  9. Train, bus via Madison

    1. Take the train from Lamy Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    36h 34m
    $471–989

  10. Train, bus

    1. Take the train from Lamy Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    37h 32m
    $544–1,169

Santa Fe to Mayo Clinic by bus, train, and foot

Calendar7Weekly Services
Duration36h 34mAverage Duration
Ticket$471Cheapest Price
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Questions & Answers

Map of how to get from Santa Fe to Mayo Clinic.ExpandLaunch map view
  • Distance: 939.3 mi
  • Duration: 7h 39m

What companies run services between Santa Fe, NM, USA and Mayo Clinic, MN, USA?

American Airlines, United Airlines, and Delta fly from Santa Fe Municipal Airport (SAF) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Downtown Transit Center to Mayo Clinic via Santa Fe, Albuquerque, Albuquerque Bus Station, Tulsa, St. Paul, and Rochester in around 34h 17m.

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