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How to get fromSanta Fe to St. Louisby plane, train, bus, train (Amtrak), or car

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There are 5 ways to get from Santa Fe to St. Louis by plane, train, bus, train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Santa Fe Municipal Airport

    best
    1. Fly from Santa Fe Municipal Airport (SAF) to Lambert–St. Louis International Airport (STL)plane plane SAF - STL
    5h 30m
    $164–728

  2. Train, bus

    1. Take the train from Santa Fe Depot Rail Runner Station to Downtown Albuquerque Rail Runner Stationtrain train Nmrx
    2. Take the bus from Albuquerque Bus Station to St Louis Bus Stationbus bus Greyhound US1210
    23h 40m
    $166–318

  3. Train (Amtrak)

    1. Take the train from Lamy Station to Kansas Citytrain train Southwest Chief
    2. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    24h 52m
    $356–749

  4. Drive 999.5 mi

    1. Drive from Santa Fe to St. Louiscar car 999.5 mi
    17h 4m
    $183–264

  5. Train to Albuquerque International Airport, fly

    1. Take the train from Santa Fe Depot Rail Runner Station to Downtown Albuquerque Rail Runner Stationtrain train
    2. Fly from Albuquerque International Airport (ABQ) to Lambert–St. Louis International Airport (STL)plane plane ABQ - STL
    8h 41m
    $179–812

Santa Fe to St. Louis by train and bus

Calendar14Weekly Services
Duration23h 40mAverage Duration
Ticket$166Cheapest Price
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Questions & Answers

Map of how to get from Santa Fe to St. Louis.ExpandLaunch map view
  • Distance: 914.7 mi
  • Duration: 5h 30m

What companies run services between Santa Fe, NM, USA and St. Louis, MO, USA?

United Airlines and American Airlines fly from Santa Fe Municipal Airport (SAF) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Santa Fe Amtrak Station to St. Louis via Lamy Station, Lamy Station, and Kansas City in around 24h 52m.

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