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How to get fromSanta Margherita to Sienaby train (Trenitalia), bus, car, plane, or train

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There are 6 ways to get from Santa Margherita to Siena by train (Trenitalia), bus, car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Trenitalia)

    best
    1. Take the train from Milano P.Garibaldi to Firenze S.M.N.train train Fr
    2. Take the train from Firenze S.M.N. to Sienatrain train Re
    5h 25m
    €59–112

  2. Bus

    cheapest
    1. Take the bus from Milan to Sienabus bus 528
    6h 44m
    €32–63

  3. Drive 381.5 km

    1. Drive from Santa Margherita to Sienacar car 381.5 km
    3h 50m
    €60–87

  4. Fly from Milan Linate Airport, train

    1. Fly from Milan Linate Airport (LIN) to Florence Peretola Airport (FLR)plane plane LIN - FLR
    2. Take the train from Firenze S.M.N. to Sienatrain train
    6h 17m
    €117–296

  5. Train, bus

    1. Take the train from Rho-Fiera Milano to Florence Santa Maria Novellatrain train 9963 / ...
    2. Take the bus from Firenze Autostazione to Siena-Via Tozzibus bus 131R / ...
    5h 40m
    €48–90

  6. Fly from Milano Malpensa Airport, train

    1. Fly from Milano Malpensa Airport (MXP) to Florence Peretola Airport (FLR)plane plane MXP - FLR
    2. Take the train from Firenze S.M.N. to Sienatrain train
    7h 47m
    €109–218

Santa Margherita to Siena by train (Trenitalia)

Calendar64Weekly Trains
Duration5h 25mAverage Duration
Ticket€59Cheapest Price
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Questions & Answers

Map of how to get from Santa Margherita to Siena.ExpandLaunch map view
  • Distance: 416.9 km
  • Duration: 5h 25m

What companies run services between Santa Margherita, Lombardy, Italy and Siena, Italy?

You can take a train from Desio to Siena via Milano P.Garibaldi and Firenze S.M.N. in around 5h 25m. Alternatively, FlixBus operates a bus from Milan to Siena 5 times a week. Tickets cost €30–60 and the journey takes 5h 30m.

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