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How to get fromSanta Maria Novella to Vatican Museumsby train, bus, car, plane, or train (Trenitalia)

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There are 6 ways to get from Santa Maria Novella to Vatican Museums by train, bus, car, plane, or train (Trenitalia)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, line 64 bus

    best
    1. Take the train from Florence Santa Maria Novella to Roma Terminitrain train 9927 / ...
    2. Take the bus from Termini to Cavalleggeri/S. Pietrobus bus 64 / ...
    2h
    €35–74
  2. Bus

    cheapest
    1. Take the bus from Florence to Roma, Autostazione Tiburtinabus bus N520 / ...
    4h 39m
    €15–48
  3. Drive 276 km

    1. Drive from Santa Maria Novella to Vatican Museumscar car 276 km
    2h 42m
    €44–63
  4. Fly from Florence Peretola Airport

    1. Fly from Florence Peretola Airport (FLR) to Fiumicino International Airport (FCO)plane plane FLR - FCO
    3h 19m
    €70–198
  5. Train (Trenitalia)

    1. Take the train from Firenze S.M.N. to Roma Terminitrain train Fr
    2h 15m
    €30–78
  6. Train to Bologna Guglielmo Marconi Airport, fly

    1. Take the train from Firenze S.M.N. to Bologna Centraletrain train
    2. Fly from Bologna Guglielmo Marconi Airport (BLQ) to Fiumicino International Airport (FCO)plane plane BLQ - FCO
    3h 57m
    €53–205

Santa Maria Novella to Vatican Museums by foot and bus

Calendar14Weekly Services
Duration4h 39mAverage Duration
Ticket€15Cheapest Price
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Questions & Answers

What companies run services between Santa Maria Novella, Italy and Vatican Museums, Vatican City?

FlixBus operates a bus from Florence to Roma, Autostazione Tiburtina twice daily. Tickets cost €23–40 and the journey takes 3h 25m. TTI Leonettibus SRL also services this route once a week. Alternatively, ITA Airways flies from Florence Peretola Airport (FLR) to Fiumicino International Airport (FCO) 4 times a day.

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Bus operators

Want to know more about travelling around Vatican City

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