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How to get fromSanta Maria to San Ysidroby bus, plane, train (Amtrak), car, or bus (Flixbus, Greyhound)

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There are 7 ways to get from Santa Maria to San Ysidro by bus, plane, train (Amtrak), car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Santa Barbara Municipal Airport, fly

    best
    1. Take the bus from Santa Maria Airport, CA to Santa Barbara Airportbus bus
    2. Fly from Santa Barbara Municipal Airport (SBA) to San Diego International Airport (SAN)plane plane SBA - SAN
    6h 3m
    $140–317

  2. Bus via Santa Barbara

    cheapest
    1. Take the bus from Santa Maria Transit Center to Chapala at Figueroabus bus
    2. Take the bus from Santa Barbara Bus Stop to Los Angeles Union Stationbus bus
    3. Take the bus from Los Angeles Union Station to San Ysidrobus bus
    10h 45m
    $48–79

  3. Bus

    1. Take the bus from Santa Maria Airport, CA to Los Angeles Airport, CAbus bus
    2. Take the bus from LAX Terminal 3 Shared Rides Stop to San Diegobus bus reLAXsan
    10h 16m
    $146–223

  4. Train (Amtrak)

    1. Take the train from Guadalupe Amtrak Station to San Diegotrain train Pacific Surfliner
    10h 31m
    $99–227

  5. Drive 291 mi

    1. Drive from Santa Maria to San Ysidrocar car 291 mi
    5h 12m
    $54–77

  6. Bus to San Luis Obispo County Regional Airport, fly

    1. Take the bus from Santa Maria Transit Center to Government Centerbus bus
    2. Fly from San Luis Obispo County Regional Airport (SBP) to San Diego International Airport (SAN)plane plane SBP - SAN
    6h 37m
    $178–375

  7. Bus to Los Angeles International Airport, fly

    1. Take the bus from Santa Maria Airport, CA to Los Angeles Airport, CAbus bus
    2. Fly from Los Angeles International Airport (LAX) to San Diego International Airport (SAN)plane plane LAX - SAN
    8h 41m
    $250–672

Santa Maria to San Ysidro by bus

Calendar41Weekly Buses
Duration10h 16mAverage Duration
Ticket$146Cheapest Price
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Questions & Answers

Map of how to get from Santa Maria to San Ysidro.ExpandLaunch map view
  • Distance: 280.5 mi
  • Duration: 6h 3m

What companies run services between Santa Maria, Santa Barbara County, CA, USA and San Ysidro, CA, USA?

You can take a bus from Transit Center to San Ysidro Bl & I-805 via Santa Maria Public Airport, Santa Maria Airport, CA, Los Angeles Airport, CA, LAX Terminal 3 Shared Rides Stop, San Diego Greyhound Bus Stop, and San Ysidro Transit Center in around 10h 16m. Alternatively, Amtrak operates a train from Guadalupe Amtrak Station to San Diego 3 times a day. Tickets cost $95–210 and the journey takes 8h 21m.

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