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How to get fromSanta Maria to St. Louisby bus, plane, bus (Greyhound), train (Amtrak), or car

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There are 8 ways to get from Santa Maria to St. Louis by bus, plane, bus (Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Santa Barbara Municipal Airport, fly

    best
    1. Take the bus from Santa Maria Airport, CA to Santa Barbara Airportbus bus
    2. Fly from Santa Barbara Municipal Airport (SBA) to Lambert–St. Louis International Airport (STL)plane plane SBA - STL
    9h 30m
    $204–680

  2. Bus to San Luis Obispo County Regional Airport, fly

    cheapest
    1. Take the bus from Santa Maria Transit Center to Government Centerbus bus
    2. Fly from San Luis Obispo County Regional Airport (SBP) to Lambert–St. Louis International Airport (STL)plane plane SBP - STL
    9h 49m
    $157–658

  3. Bus

    1. Take the bus from Santa Maria Airport, CA to Los Angeles Airport, CAbus bus
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus Greyhound US1210
    47h 12m
    $374–665

  4. Train via Kansas City (Amtrak)

    1. Take the train from Guadalupe Amtrak Station to Los Angelestrain train
    2. Take the train from Los Angeles to Kansas Citytrain train
    3. Take the train from Kansas City to St. Louistrain train
    2d 1h
    $697–1,522

  5. Drive 1,931.8 mi

    1. Drive from Santa Maria to St. Louiscar car 1,931.8 mi
    31h 40m
    $353–510

  6. Bus to Los Angeles International Airport, fly

    1. Take the bus from Santa Maria Airport, CA to Los Angeles Airport, CAbus bus
    2. Fly from Los Angeles International Airport (LAX) to Lambert–St. Louis International Airport (STL)plane plane LAX - STL
    10h 12m
    $219–405

  7. Fly from Santa Maria Airport

    1. Fly from Santa Maria Airport (SMX) to Lambert–St. Louis International Airport (STL)plane plane SMX - STL
    10h 30m
    $205–855

  8. Train (Amtrak)

    1. Take the train from Guadalupe Amtrak Station to Los Angelestrain train Pacific Surfliner
    2. Take the train from Los Angeles to St. Louistrain train Texas Eagle
    2d 15h
    $812–1,732

Santa Maria to St. Louis by bus

Calendar14Weekly Buses
Duration47h 12mAverage Duration
Ticket$374Cheapest Price
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Questions & Answers

Map of how to get from Santa Maria to St. Louis.ExpandLaunch map view
  • Distance: 1,739.8 mi
  • Duration: 9h 30m

What companies run services between Santa Maria, Santa Barbara County, CA, USA and St. Louis, MO, USA?

You can take a bus from Transit Center to St Louis Bus Station via Santa Maria Public Airport, Santa Maria Airport, CA, LAX Tom Bradley International Terminal, and Los Angeles Union Station in around 47h 12m. Alternatively, you can take a bus from Main at Pine Outbound to St. Louis via Guadalupe Amtrak Station, Guadalupe Amtrak Station, Los Angeles, and Kansas City in around 2d 1h.

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