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How to get fromSanta Rosa to Knoxvilleby plane, bus, train, bus (Greyhound), car, or subway

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There are 8 ways to get from Santa Rosa to Knoxville by plane, bus, train, bus (Greyhound), car, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Sonoma County Airport

    best
    1. Fly from Sonoma County Airport (STS) to Mcghee Tyson Airport (TYS)plane plane STS - TYS
    8h 32m
    $371–1,425

  2. Train, bus to San Francisco International Airport, fly

    cheapest
    1. Take the train from SMART Santa Rosa Downtown to SMART Larkspurtrain train
    2. Take the bus from Larkspur - pickup to San Francisco Airportbus bus
    3. Fly from San Francisco International Airport (SFO) to Mcghee Tyson Airport (TYS)plane plane SFO - TYS
    10h 9m
    $368–1,309

  3. Bus, train

    1. Take the bus from Santa Rosa Amtrak Bus Stop to Martinezbus bus
    2. Take the train from Martinez to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus
    3d 17h

  4. Bus

    1. Take the bus from Santa Rosa to Phoenix Bus Stationbus bus
    2. Take the bus from Phoenix Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    4. Take the bus from New York to Knoxvillebus bus
    3d 19h
    $696–1,028

  5. Drive  2,508.6 mi

    1. Drive from Santa Rosa to Knoxvillecar car 2,508.6 mi
    40h 9m
    $458–662

  6. Train, bus to Oakland International Airport, fly

    1. Take the train from SMART Santa Rosa Downtown to SMART San Rafaeltrain train
    2. Take the bus from San Rafael to Oakland International Airportbus bus
    3. Fly from Oakland International Airport (OAK) to Mcghee Tyson Airport (TYS)plane plane OAK - TYS
    10h 14m
    $421–1,631

  7. Train, BART to Norman Y. Mineta San José International Airport, fly

    1. Take the train from SMART Santa Rosa Downtown to SMART San Rafaeltrain train
    2. Take the subway from El Cerrito Del Norte to Milpitassubway subway
    3. Fly from Norman Y. Mineta San José International Airport (SJC) to Mcghee Tyson Airport (TYS)plane plane SJC - TYS
    11h 27m
    $402–1,499

  8. Bus, train via Chicago

    1. Take the bus from Santa Rosa Amtrak Bus Stop to Martinezbus bus
    2. Take the train from Martinez to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to New York Midtownbus bus
    4. Take the bus from New York to Knoxvillebus bus
    3d 17h

Sonoma County Airport (STS) to Mcghee Tyson Airport (TYS) flights

Calendar7Weekly Planes
Duration8h 16mAverage Duration
Ticket$304Cheapest Price
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Comparing Your Travel Options

Map of how to get from Santa Rosa to Knoxville.ExpandLaunch map view
  • Distance: 2,151.7 mi
  • Duration: 8h 32m

What companies run services between Santa Rosa, CA, USA and Knoxville, TN, USA?

American Airlines, Southwest Airlines, and Allegiant Air fly from Sonoma County Airport (STS) to Mcghee Tyson Airport (TYS) once daily. Alternatively, you can take a bus from Santa Rosa to Knoxville via Phoenix Bus Station, St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 3d 19h.

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