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How to get fromSantee to Jacksonvilleby taxi, bus, car, train, plane, or bus (Flixbus, Greyhound)

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There are 7 ways to get from Santee to Jacksonville by taxi, bus, car, train, plane, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi, bus (Greyhound)

    best
    1. Take the taxi from Santee to Walterboro, SCtaxi taxi
    2. Take the bus from Walterboro, SC to Jacksonvillebus bus Greyhound US0644S
    4h 31m
    $132–185

  2. Drive 240.4 mi

    cheapest
    1. Drive from Santee to Jacksonvillecar car 240.4 mi
    3h 55m
    $44–64

  3. Drive, train (Amtrak)

    1. Drive from Santee to Charleston Amtrak Stationcar car
    2. Take the train from Charleston Amtrak Station to Jacksonvilletrain train Silver Meteor
    6h 19m
    $92–188

  4. Drive to Columbia, fly

    1. Drive from Santee to Columbia-Airport-CAEcar car
    2. Fly from Columbia (CAE) to Jacksonville (JAX)plane plane CAE - JAX
    5h 41m
    $152–868

  5. Bus

    1. Take the bus from Orangeburg to Jacksonvillebus bus FlixBus 2433
    5h 8m
    $118–173

  6. Drive to Charleston International Airport, fly

    1. Drive from Santee to Charleston-Airport-CHScar car
    2. Fly from Charleston International Airport (CHS) to Jacksonville (JAX)plane plane CHS - JAX
    6h 4m
    $77–409

  7. Drive to Augusta Regional Airport At Bush Field, fly

    1. Drive from Santee to Augusta Regional Airport At Bush Field (AGS)car car
    2. Fly from Augusta Regional Airport At Bush Field (AGS) to Jacksonville (JAX)plane plane AGS - JAX
    6h 53m
    $79–399

Columbia (CAE) to Jacksonville (JAX) flights

Calendar114Weekly Planes
Duration4h 31mAverage Duration
Ticket$147Cheapest Price
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Questions & Answers

Map of how to get from Santee to Jacksonville.ExpandLaunch map view
  • Distance: 248.7 mi
  • Duration: 4h 31m

What companies run services between Santee, SC, USA and Jacksonville, FL, USA?

Flixbus USA operates a bus from Orangeburg to Jacksonville once daily. Tickets cost $40–70 and the journey takes 4h 40m. Greyhound USA also services this route once daily.

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