There are 8 ways to get from Santee to Naples by car, plane, bus, train, taxi, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive to Charleston International Airport, fly to Fort Lauderdale–Hollywood International Airport, bus
best- Drive from Santee to Charleston-Airport-CHScar
- Fly from Charleston International Airport (CHS) to Fort Lauderdale–Hollywood International Airport (FLL)plane CHS - FLL
- Take the bus from Fort Lauderdale Airport to Naples, FLbus
5h 30m$228–1,193Drive 565.4 mi
cheapest- Drive from Santee to Naplescar 565.4 mi
9h 57m$104–149Drive, train, bus
- Drive from Santee to Charleston Amtrak Stationcar
- Take the train from Charleston Amtrak Station to Fort Lauderdale Amtrak Stationtrain
- Take the bus from Fort Lauderdale Airport to Naples, FLbus
17h 59m$259–517Taxi, bus
- Take the taxi from Santee to Walterboro, SCtaxi
- Take the bus from Walterboro, SC to Jacksonvillebus
- Take the bus from Jacksonville to Orlando Bus Stationbus
- Take the bus from Orlando Bus Station to Fort Myers Bus Stopbus
19h 26m$186–291Drive to Charleston International Airport, fly to Miami International Airport, bus
- Drive from Santee to Charleston-Airport-CHScar
- Fly from Charleston International Airport (CHS) to Miami International Airport (MIA)plane CHS - MIA
- Take the bus from Miami Airport to Naples, FLbus
5h 59m$563–1,108Drive to Charleston International Airport, fly to Ft. Myers, line 240 bus, line 600 bus, line 11 bus
- Drive from Santee to Charleston-Airport-CHScar
- Fly from Charleston International Airport (CHS) to Ft. Myers (RSW)plane CHS - RSW
- Take the bus from South Fort Myers Transfer/P&R to Coconut Point Mallbus
- Take the bus from Coconut Point Mall to Creekside Way Transfer @ Immokalee Rdbus
- Take the bus from Creekside WLinC to 3rd Ave Sbus
8h 27mDrive to Columbia, fly to Ft. Myers
- Drive from Santee to Columbia-Airport-CAEcar
- Fly from Columbia (CAE) to Ft. Myers (RSW)plane CAE - RSW
10h 46m$205–1,023Bus (Flixbus)
- Take the bus from Orangeburg to Orlando Bus Stationbus FlixBus 2433
- Take the bus from Orlando Bus Station to Fort Myers Bus Stopbus FlixBus 2421
19h 28m$176–277
Charleston International Airport (CHS) to Fort Lauderdale–Hollywood International Airport (FLL) flights
Questions & Answers
The cheapest way to get from Santee to Naples is to drive which costs $100 - $150 and takes 9h 57m.
The fastest way to get from Santee to Naples is to drive and fly and bus which takes 5h 30m and costs $220 - $1,200.
No, there is no direct bus from Santee to Naples. However, there are services departing from Orangeburg and arriving at 3rd Ave S via Orlando Bus Station, Rosa Parks Transportation Ctr, South Fort Myers Transfer/P&R, Coconut Point Mall and Creekside WLinC. The journey, including transfers, takes approximately 19h 28m.
The distance between Santee and Naples is 641 miles. The road distance is 568.7 miles.
The best way to get from Santee to Naples without a car is to taxi and bus which takes 19h 26m and costs $180 - $300.
It takes approximately 5h 30m to get from Santee to Naples, including transfers.
Santee to Naples bus services, operated by Flixbus USA, depart from Orangeburg station.
Santee to Naples bus services, operated by Flixbus USA, arrive at Orlando Bus Station.
Yes, the driving distance between Santee to Naples is 569 miles. It takes approximately 9h 57m to drive from Santee to Naples.
There are 1471+ hotels available in Naples.
What companies run services between Santee, SC, USA and Naples, FL, USA?
You can take a vehicle from Santee to 3rd Ave S via Orangeburg, Orlando Bus Station, Rosa Parks Transportation Ctr, South Fort Myers Transfer/P&R, Coconut Point Mall, Creekside Way Transfer @ Immokalee Rd, and Creekside WLinC in around 19h 28m.
- Website
- delta.com
Flights from Charleston International Airport to Fort Lauderdale–Hollywood International Airport via Atlanta
- Ave. Duration
- 4h 11m
- When
- Every day
- Estimated price
- $85–430
Flights from Charleston International Airport to Miami International Airport via Atlanta
- Ave. Duration
- 4h 18m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $85–410
Flights from Charleston International Airport to Ft. Myers via Atlanta
- Ave. Duration
- 3h 57m
- When
- Every day
- Estimated price
- $85–440
Flights from Columbia to Ft. Myers via Atlanta
- Ave. Duration
- 4h 52m
- When
- Every day
- Estimated price
- $190–1,000
- Website
- aa.com
Flights from Charleston International Airport to Fort Lauderdale–Hollywood International Airport via Charlotte
- Ave. Duration
- 4h 17m
- When
- Every day
- Estimated price
- $80–420
Flights from Charleston International Airport to Miami International Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- $60–340
Flights from Charleston International Airport to Miami International Airport via Charlotte
- Ave. Duration
- 4h 8m
- When
- Sunday
- Estimated price
- $80–410
Flights from Charleston International Airport to Ft. Myers via Charlotte
- Ave. Duration
- 3h 59m
- When
- Monday, Tuesday, Thursday, Friday, and Saturday
- Estimated price
- $85–440
Flights from Columbia to Ft. Myers via Charlotte
- Ave. Duration
- 4h 53m
- When
- Every day
- Estimated price
- $190–1,000
Flights from Columbia to Ft. Myers via Reagan Washington
- Ave. Duration
- 7h 14m
- When
- Sunday
- Estimated price
- $290–1,300
Flights from Columbia to Ft. Myers via New York La Guardia
- Ave. Duration
- 8h 5m
- When
- Every day
- Estimated price
- $360–1,500
- Website
- flybreeze.com
Flights from Charleston International Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 41m
- When
- Tuesday, Thursday, and Sunday
- Estimated price
- $120–1,100
Flights from Charleston International Airport to Ft. Myers
- Ave. Duration
- 1h 39m
- When
- Wednesday, Saturday, Monday, and Friday
- Estimated price
- $140–950
- Website
- united.com
Flights from Columbia to Ft. Myers via Newark
- Ave. Duration
- 8h 6m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $360–1,500
Flights from Columbia to Ft. Myers via Chicago O'Hare
- Ave. Duration
- 8h 11m
- When
- Every day
- Estimated price
- $380–1,600
- Website
- jetblue.com
Flights from Charleston International Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 41m
- When
- Every day
- Estimated price
- $60–350
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Charleston Amtrak Station to Fort Lauderdale Amtrak Station
- Ave. Duration
- 13h 10m
- Frequency
- Once daily
- Estimated price
- $200–420
- Website
- Amtrak
- Phone
- +1 877 733 0724
- Website
- RedCoach
Bus from Fort Lauderdale Airport to Naples, FL
- Ave. Duration
- 1h 35m
- Frequency
- Once daily
- Estimated price
- $25–50
- Website
- RedCoach
Bus from Fort Lauderdale Airport to Naples, FL
- Ave. Duration
- 1h 35m
- Frequency
- Once daily
- Estimated price
- $25–50
- Website
- RedCoach
Bus from Miami Airport to Naples, FL
- Ave. Duration
- 2h 5m
- Frequency
- Once daily
- Estimated price
- $30–65
- Website
- RedCoach
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Walterboro, SC to Jacksonville
- Ave. Duration
- 4h
- Frequency
- Twice daily
- Estimated price
- $30–65
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Jacksonville to Orlando Bus Station
- Ave. Duration
- 2h 35m
- Frequency
- Every 2 hours
- Estimated price
- $22–40
- Schedules at
- Flixbus USA
Bus from Orlando Bus Station to Fort Myers Bus Stop
- Ave. Duration
- 5h 10m
- Frequency
- Every 4 hours
- Estimated price
- $30–60
- Schedules at
- Flixbus USA
Bus from Orangeburg to Orlando Bus Station
- Ave. Duration
- 7h 30m
- Frequency
- Twice daily
- Estimated price
- $60–110
- Schedules at
- Flixbus USA
Bus from Orlando Bus Station to Fort Myers Bus Stop
- Ave. Duration
- 5h 10m
- Frequency
- Every 4 hours
- Estimated price
- $30–60
- Schedules at
- Flixbus USA
- Phone
- +1 239-533-2111
- Website
- Lee County Transit
Bus from South Fort Myers Transfer/P&R to Coconut Point Mall
- Ave. Duration
- 35 min
- Frequency
- Hourly
- Estimated price
- $1–3
- Website
- Lee County Transit
Bus from Coconut Point Mall to Creekside Way Transfer @ Immokalee Rd
- Ave. Duration
- 38 min
- Frequency
- Hourly
- Estimated price
- $1–3
- Website
- Lee County Transit
- Phone
- +1 239-252-7777
- Website
- Collier Area Transit
Bus from Creekside WLinC to 3rd Ave S
- Ave. Duration
- 34 min
- Frequency
- Hourly
- Website
- Collier Area Transit
- Ave. Duration
- 31 min
- Estimated price
- $100–120
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