There are 6 ways to get from Santee to Palm Coast by taxi, bus, car, train, plane, or bus (Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Taxi, bus
best- Take the taxi from Santee to Walterboro, SCtaxi
- Take the bus from Walterboro, SC to Jacksonvillebus
- Take the bus from Jacksonville to Palm Coast Bus Stopbus
6h 58m$165–233Drive 301.9 mi
cheapest- Drive from Santee to Palm Coastcar 301.9 mi
4h 58m$56–80Drive, train, bus
- Drive from Santee to Charleston Amtrak Stationcar
- Take the train from Charleston Amtrak Station to Jacksonvilletrain
- Take the bus from Jacksonville to Palm Coast Bus Stopbus
8h 51m$125–236Drive to Columbia, fly, taxi
- Drive from Santee to Columbia-Airport-CAEcar
- Fly from Columbia (CAE) to Daytona Beach International Airport (DAB)plane CAE - DAB
- Take the taxi from Daytona-Beach-Airport-DAB to Palm Coasttaxi
5h 16m$271–1,205Bus
- Take the bus from Orangeburg to Jacksonvillebus FlixBus 2433
- Take the bus from Jacksonville to Palm Coast Bus Stopbus FlixBus 2431
7h 35m$151–221Drive to Charleston International Airport, fly, taxi
- Drive from Santee to Charleston-Airport-CHScar
- Fly from Charleston International Airport (CHS) to Daytona Beach International Airport (DAB)plane CHS - DAB
- Take the taxi from Daytona-Beach-Airport-DAB to Palm Coasttaxi
5h 6m$171–606
Columbia (CAE) to Daytona Beach International Airport (DAB) flights
Questions & Answers
The cheapest way to get from Santee to Palm Coast is to drive which costs $55 - $80 and takes 4h 58m.
The fastest way to get from Santee to Palm Coast is to drive which takes 4h 58m and costs $55 - $80.
No, there is no direct bus from Santee to Palm Coast. However, there are services departing from Orangeburg and arriving at Palm Coast Bus Stop via Jacksonville. The journey, including transfers, takes approximately 7h 35m.
The distance between Santee and Palm Coast is 328 miles. The road distance is 303.7 miles.
The best way to get from Santee to Palm Coast without a car is to taxi and bus which takes 6h 58m and costs $160 - $240.
It takes approximately 6h 58m to get from Santee to Palm Coast, including transfers.
Santee to Palm Coast bus services, operated by Flixbus USA, depart from Orangeburg station.
Santee to Palm Coast bus services, operated by Flixbus USA, arrive at Jacksonville station.
Yes, the driving distance between Santee to Palm Coast is 304 miles. It takes approximately 4h 58m to drive from Santee to Palm Coast.
There are 454+ hotels available in Palm Coast.
What companies run services between Santee, SC, USA and Palm Coast, FL, USA?
You can take a vehicle from Santee to Palm Coast via Orangeburg, Jacksonville, and Palm Coast Bus Stop in around 7h 35m.
- Website
- delta.com
Flights from Columbia to Daytona Beach International Airport via Atlanta
- Ave. Duration
- 3h 49m
- When
- Every day
- Estimated price
- $200–1,200
Flights from Charleston International Airport to Daytona Beach International Airport via Atlanta
- Ave. Duration
- 4h 10m
- When
- Every day
- Estimated price
- $95–550
- Website
- aa.com
Flights from Columbia to Daytona Beach International Airport via Charlotte
- Ave. Duration
- 4h 50m
- When
- Every day
- Estimated price
- $190–1,100
Flights from Charleston International Airport to Daytona Beach International Airport via Charlotte
- Ave. Duration
- 4h 45m
- When
- Every day
- Estimated price
- $90–500
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Charleston Amtrak Station to Jacksonville
- Ave. Duration
- 4h 28m
- Frequency
- Once daily
- Estimated price
- $80–170
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Walterboro, SC to Jacksonville
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $30–65
- Website
- https://www.greyhound.com/
Bus from Jacksonville to Palm Coast Bus Stop
- Ave. Duration
- 1h 5m
- Frequency
- Once daily
- Estimated price
- $10–20
- Website
- https://www.greyhound.com/
Bus from Jacksonville to Palm Coast Bus Stop
- Ave. Duration
- 1h 5m
- Frequency
- Once daily
- Estimated price
- $10–20
- Website
- https://www.greyhound.com/
Bus from Orangeburg to Jacksonville
- Ave. Duration
- 4h 50m
- Frequency
- Once daily
- Estimated price
- $35–75
- Website
- https://www.greyhound.com/
Bus from Jacksonville to Palm Coast Bus Stop
- Ave. Duration
- 1h 5m
- Frequency
- Once daily
- Estimated price
- $10–20
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Jacksonville to Palm Coast Bus Stop
- Ave. Duration
- 1h 15m
- Frequency
- Once daily
- Estimated price
- $11–19
- Schedules at
- flixbus.com
Bus from Jacksonville to Palm Coast Bus Stop
- Ave. Duration
- 1h 15m
- Frequency
- Once daily
- Estimated price
- $11–19
- Schedules at
- flixbus.com
Bus from Orangeburg to Jacksonville
- Ave. Duration
- 4h 40m
- Frequency
- Once daily
- Estimated price
- $40–70
- Schedules at
- flixbus.com
Bus from Jacksonville to Palm Coast Bus Stop
- Ave. Duration
- 1h 15m
- Frequency
- Once daily
- Estimated price
- $11–19
- Schedules at
- flixbus.com
- Ave. Duration
- 36 min
- Estimated price
- $70–120
American Taxi
- Phone
- +1 386-255-0000
- Website
- facebook.com
Daytona Taxi
- Phone
- +1 386-255-5555
- Website
- daytonataxi.com
American Taxi
- Phone
- +1 386-255-0000
- Website
- facebook.com
Daytona Taxi
- Phone
- +1 386-255-5555
- Website
- daytonataxi.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide






