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How to get fromSanti Cosma e Damiano to Florenceby train (Trenitalia), bus, car, train, or plane

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There are 8 ways to get from Santi Cosma e Damiano to Florence by train (Trenitalia), bus, car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Trenitalia)

    best
    1. Take the train from Minturno-Scauri to Roma Terminitrain train Re
    2. Take the train from Roma Termini to Firenze S.M.N.train train Fr
    3h 50m
    €77–146

  2. Bus

    cheapest
    1. Take the bus from Cassino to Florence Villa Constanza Bus Stationbus bus 532
    7h 18m
    €33–63

  3. Drive 400.1 km

    1. Drive from Santi Cosma e Damiano to Florencecar car 400.1 km
    4h
    €62–90

  4. Bus, train to Fiumicino International Airport, fly to Florence Peretola Airport

    1. Take the bus from CASTELFORTE | Via Risorgimento Via Toselli # f4578 to FORMIA | Porto # f99992bus bus
    2. Take the train from Formia-Gaeta to Roma Terminitrain train
    3. Fly from Fiumicino International Airport (FCO) to Florence Peretola Airport (FLR)plane plane FCO - FLR
    5h 20m
    €81–229

  5. Bus, train

    1. Take the bus from COSMA -DAMIANO | staz. Carabineri # f6675 to FORMIA | Porto # f99992bus bus
    2. Take the train from Formia-Gaeta to Roma Terminitrain train Ic
    3. Take the train from Roma Termini to Firenze S.M.N.train train Fr
    4h 17m
    €43–110

  6. Bus, train via Monte San Biagio

    1. Take the bus from COSMA -DAMIANO | staz. Carabineri # f6675 to MONTE S. BIAGIO | Stazione FS # f4110bus bus
    2. Take the train from Monte San Biagio - Terracina Mare to Roma Terminitrain train Re
    3. Take the train from Roma Termini to Firenze Santa Maria Novellatrain train
    5h 31m
    €45–90

  7. Train to Naples Airport, fly to Florence Peretola Airport

    1. Take the train from Formia-Gaeta to Napoli Centraletrain train
    2. Fly from Naples Airport (NAP) to Florence Peretola Airport (FLR)plane plane NAP - FLR
    7h 16m
    €99–225

  8. Train to Fiumicino International Airport, fly to Bologna Guglielmo Marconi Airport, train

    1. Take the train from Formia-Gaeta to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Bologna Guglielmo Marconi Airport (BLQ)plane plane FCO - BLQ
    3. Take the train from Bologna Centrale to Firenze S.M.N.train train
    6h 1m
    €68–194

Santi Cosma e Damiano to Florence by bus

Calendar5Weekly Buses
Duration7h 18mAverage Duration
Ticket€33Cheapest Price
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Questions & Answers

Map of how to get from Santi Cosma e Damiano to Florence.ExpandLaunch map view
  • Distance: 411.4 km
  • Duration: 3h 50m

What companies run services between Santi Cosma e Damiano, Lazio, Italy and Florence, Italy?

You can take a vehicle from Santi Cosma e Damiano to Firenze S.M.N. via Minturno-Scauri and Roma Termini in around 3h 50m. Alternatively, FlixBus operates a bus from Cassino to Florence Villa Constanza Bus Station once daily. Tickets cost €30–60 and the journey takes 5h 15m.

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