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How to get fromSantiago to Cuscoby bus, car, plane, or taxi

Find Transport to Cusco

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There are 6 ways to get from Santiago to Cusco by bus, car, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Ica to Cuscobus bus Ica
    15h 6m
    $45–67

  2. Bus via Cusco

    cheapest
    1. Take the bus from Ica to Cuscobus bus Lima
    18h 35m
    $40–72

  3. Drive 749.8 km

    1. Drive from Santiago to Cuscocar car 749.8 km
    12h 57m
    $113–163

  4. Bus to Coronel Fap Alfredo Mendívil Duarte Airport, fly

    1. Take the bus from Ica to Ayacuchobus bus
    2. Fly from Coronel Fap Alfredo Mendívil Duarte Airport (AYP) to Alejandro Velasco Astete International Airport (CUZ)plane plane AYP - CUZ
    10h 27m
    $127–331

  5. Bus, taxi to Francisco Carle Airport, fly

    1. Take the bus from Ica to Huancayobus bus
    2. Take the taxi from Huancayo to Francisco Carle Airport (JAU)taxi taxi
    3. Fly from Francisco Carle Airport (JAU) to Alejandro Velasco Astete International Airport (CUZ)plane plane JAU - CUZ
    11h 24m
    $193–415

  6. Bus to Jorge Chávez International Airport, fly

    1. Take the bus from Ica to Limabus bus
    2. Fly from Jorge Chávez International Airport (LIM) to Alejandro Velasco Astete International Airport (CUZ)plane plane LIM - CUZ
    9h 44m
    $79–182

Coronel Fap Alfredo Mendívil Duarte Airport (AYP) to Alejandro Velasco Astete International Airport (CUZ) flights

Calendar49Weekly Planes
Duration5h 20mAverage Duration
Ticket$102Cheapest Price
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Questions & Answers

Map of how to get from Santiago to Cusco.ExpandLaunch map view
  • Distance: 783.6 km
  • Duration: 15h 6m

What companies run services between Santiago, Ica, Peru and Cusco, Peru?

CIVA operates a bus from Ica to Cusco twice daily. Tickets cost $35–55 and the journey takes 14h 52m.

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Want to know more about travelling around the world?

Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including How to get from JFK to New York City, Want to know more about Flixbus?, and Why you should take the train in the US - to help you get the most out of your next trip.